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Hepatic Unsaturated...
Hepatic Unsaturated Fatty Acids Are Linked to Lower Degree of Fibrosis in Non-alcoholic Fatty Liver Disease
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- Fridén, Michael (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Rosqvist, Fredrik, 1985- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.
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- Niessen, Heiko G. (author)
- Boehringer Ingelheim Pharma GmbH,Boehringer Ingelheim Pharma GmbH & Co KG, Dept Translat Med & Clin Pharmacol, Biberach, Germany.
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- Schultheis, Christian (author)
- Boehringer Ingelheim Pharma GmbH,Boehringer Ingelheim Pharma GmbH & Co KG, Dept Translat Med & Clin Pharmacol, Biberach, Germany.
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- Hockings, Paul, 1956 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Antaros Medical AB,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.;Chalmers Univ Technol, MedTech West, Gothenburg, Sweden.
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- Hulthe, Johannes, 1970 (author)
- Antaros Medical AB,Antaros Med AB, BioVenture Hub, Mölndal, Sweden.
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- Gummesson, Anders, 1973 (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Clin Genet & Genom, Gothenburg, Sweden.
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- Wanders, Alkwin (author)
- Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark.
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- Rorsman, Fredrik, Docent, 1960- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Vessby, Johan, 1972- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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(creator_code:org_t)
- 2022-01-10
- 2022
- English.
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In: Frontiers in Medicine. - : Frontiers Media SA. - 2296-858X. ; 8
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Abstract
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- Background: The hepatic lipidome of patients with early stages of non-alcoholic fatty liver disease (NAFLD) has been fairly well-explored. However, studies on more progressive forms of NAFLD, i.e., liver fibrosis, are limited. Materials and methods: Liver fatty acids were determined in cholesteryl esters (CE), phospholipids (PL), and triacylglycerols (TAG) by gas chromatography. Cross-sectional associations between fatty acids and biopsy-proven NAFLD fibrosis (n = 60) were assessed using multivariable logistic regression models. Stages of fibrosis were dichotomized into none-mild (F0–1) or significant fibrosis (F2–4). Models were adjusted for body-mass index (BMI), age and patatin-like phospholipase domain-containing protein 3 (PNPLA3 rs738409) (I148M) genotype. A secondary analysis examined whether associations from the primary analysis could be confirmed in the corresponding plasma lipid fractions. Results: PL behenic acid (22:0) was directly associated [OR (95% CI): 1.86 (1.00, 3.45)] whereas PL docosahexaenoic acid (22:6n-3) [OR (95% CI): 0.45 (0.23, 0.89)], TAG oleic acid (18:1n-9) [OR (95% CI): 0.52 (0.28, 0.95)] and 18:1n-9 and vaccenic acid (18:1n-7) (18:1) [OR (95% CI): 0.52 (0.28, 0.96)] were inversely associated with liver fibrosis. In plasma, TAG 18:1n-9 [OR (95% CI): 0.55 (0.31, 0.99)], TAG 18:1 [OR (95% CI): 0.54 (0.30, 0.97)] and PL 22:0 [OR (95% CI): 0.46 (0.25, 0.86)] were inversely associated with liver fibrosis. Conclusion: Higher TAG 18:1n-9 levels were linked to lower fibrosis in both liver and plasma, possibly reflecting an altered fatty acid metabolism. Whether PL 22:6n-3 has a protective role, together with a potentially adverse effect of hepatic 22:0, on liver fibrosis warrants large-scale studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- NAFLD
- fibrosis
- biomarkers
- lipids
- fatty acids
Publication and Content Type
- art (subject category)
- ref (subject category)
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Fridén, Michael
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Rosqvist, Fredri ...
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Ahlström, Håkan, ...
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Niessen, Heiko G ...
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Schultheis, Chri ...
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Hockings, Paul, ...
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Hulthe, Johannes ...
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Gummesson, Ander ...
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Wanders, Alkwin
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Rorsman, Fredrik ...
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Risérus, Ulf, 19 ...
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Vessby, Johan, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Frontiers in Med ...
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Chalmers University of Technology
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Uppsala University