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Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
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- Martins, Murillo L. (author)
- Universidade Estadual Paulista (UNESP),São Paulo State University (UNESP),Niels Bohr Institute
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- Orecchini, A. (author)
- Universita degli Studi di Perugia,University of Perugia,Institut Laue-Langevin
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- Aguilera Medina, Luis, 1983 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- 2015-01-23
- 2015
- English.
- In: EPJ Web of Conferences. - : EDP Sciences. - 2101-6275 .- 2100-014X. ; 83
- Conference paper (peer-reviewed)
Abstract
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- The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
Subject headings
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
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