In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility

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Alminger, Marie,1957Chalmers tekniska högskola,Chalmers University of Technology (author)

In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility

Article/chapterEnglish2014

Publisher, publication year, extent ...

2014-06-21
Wiley,2014
electronicrdacarrier

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LIBRIS-ID:oai:research.chalmers.se:195b4b1e-71f8-4180-a8bb-0e36cea686c8
https://doi.org/10.1111/1541-4337.12081DOI
https://research.chalmers.se/publication/200688URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:for swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

There is an increased interest in secondary plant metabolites, such as polyphenols and carotenoids, due to their proposed health benefits. Much attention has focused on their bioavailability, a prerequisite for further physiological functions. As human studies are time consuming, costly, and restricted by ethical concerns, in vitro models for investigating the effects of digestion on these compounds have been developed and employed to predict their release from the food matrix, bioaccessibility, and assess changes in their profiles prior to absorption. Most typically, models simulate digestion in the oral cavity, the stomach, the small intestine, and, occasionally, the large intestine. A plethora of models have been reported, the choice mostly driven by the type of phytochemical studied, whether the purpose is screening or studying under close physiological conditions, and the availability of the model systems. Unfortunately, the diversity of model conditions has hampered the ability to compare results across different studies. For example, there is substantial variability in the time of digestion, concentrations of salts, enzymes, and bile acids used, pH, the inclusion of various digestion stages; and whether chosen conditions are static (with fixed concentrations of enzymes, bile salts, digesta, and so on) or dynamic (varying concentrations of these constituents). This review presents an overview of models that have been employed to study the digestion of both lipophilic and hydrophilic phytochemicals, comparing digestive conditions in vitro and in vivo and, finally, suggests a set of parameters for static models that resemble physiological conditions.

Subject headings and genre

LANTBRUKSVETENSKAPER Lantbruksvetenskap, skogsbruk och fiske Livsmedelsvetenskap hsv//swe
AGRICULTURAL SCIENCES Agriculture, Forestry and Fisheries Food Science hsv//eng
TEKNIK OCH TEKNOLOGIER Annan teknik Livsmedelsteknik hsv//swe
ENGINEERING AND TECHNOLOGY Other Engineering and Technologies Food Engineering hsv//eng
in vitro models
bioacessibility
carotenoids
gastrointestinal digestion
polyphenols
phytochemicals

Added entries (persons, corporate bodies, meetings, titles ...)

Aura, A. M.Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT) (author)
Bohn, T. (author)
Dufour, C. (author)
El, S. N.Ege Universitesi,Ege University (author)
Gomes, A.Nova University of Lisbon, Portugal (author)
Karakaya, S.Ege Universitesi,Ege University (author)
Martinez-Cuesta, M. C.Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL) (author)
McDougall, G. J.The James Hutton Institute (author)
Requena, T.Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL) (author)
Santos, C. N.Nova University of Lisbon, Portugal (author)
Chalmers tekniska högskolaTeknologian Tutkimuskeskus (VTT) (creator_code:org_t)

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In:Comprehensive Reviews in Food Science and Food Safety: Wiley13:4, s. 413-4361541-4337

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