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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04499naa a2200529 4500 | |
| 001 | oai:research.chalmers.se:195b4b1e-71f8-4180-a8bb-0e36cea686c8 | |
| 003 | SwePub | |
| 008 | 171008s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://doi.org/10.1111/1541-4337.120812 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/2006882 URI |
| 040 | a (SwePub)cth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Alminger, Marie,d 1957u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)mariealm |
| 245 | 1 0 | a In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility |
| 264 | c 2014-06-21 | |
| 264 | 1 | b Wiley,c 2014 |
| 338 | a electronic2 rdacarrier | |
| 520 | a There is an increased interest in secondary plant metabolites, such as polyphenols and carotenoids, due to their proposed health benefits. Much attention has focused on their bioavailability, a prerequisite for further physiological functions. As human studies are time consuming, costly, and restricted by ethical concerns, in vitro models for investigating the effects of digestion on these compounds have been developed and employed to predict their release from the food matrix, bioaccessibility, and assess changes in their profiles prior to absorption. Most typically, models simulate digestion in the oral cavity, the stomach, the small intestine, and, occasionally, the large intestine. A plethora of models have been reported, the choice mostly driven by the type of phytochemical studied, whether the purpose is screening or studying under close physiological conditions, and the availability of the model systems. Unfortunately, the diversity of model conditions has hampered the ability to compare results across different studies. For example, there is substantial variability in the time of digestion, concentrations of salts, enzymes, and bile acids used, pH, the inclusion of various digestion stages; and whether chosen conditions are static (with fixed concentrations of enzymes, bile salts, digesta, and so on) or dynamic (varying concentrations of these constituents). This review presents an overview of models that have been employed to study the digestion of both lipophilic and hydrophilic phytochemicals, comparing digestive conditions in vitro and in vivo and, finally, suggests a set of parameters for static models that resemble physiological conditions. | |
| 650 | 7 | a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Livsmedelsvetenskap0 (SwePub)401032 hsv//swe |
| 650 | 7 | a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Food Science0 (SwePub)401032 hsv//eng |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Annan teknikx Livsmedelsteknik0 (SwePub)211012 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Other Engineering and Technologiesx Food Engineering0 (SwePub)211012 hsv//eng |
| 653 | a in vitro models | |
| 653 | a bioacessibility | |
| 653 | a carotenoids | |
| 653 | a gastrointestinal digestion | |
| 653 | a polyphenols | |
| 653 | a phytochemicals | |
| 700 | 1 | a Aura, A. M.u Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT)4 aut |
| 700 | 1 | a Bohn, T.4 aut |
| 700 | 1 | a Dufour, C.4 aut |
| 700 | 1 | a El, S. N.u Ege Universitesi,Ege University4 aut |
| 700 | 1 | a Gomes, A.u Nova University of Lisbon, Portugal4 aut |
| 700 | 1 | a Karakaya, S.u Ege Universitesi,Ege University4 aut |
| 700 | 1 | a Martinez-Cuesta, M. C.u Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL)4 aut |
| 700 | 1 | a McDougall, G. J.u The James Hutton Institute4 aut |
| 700 | 1 | a Requena, T.u Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL)4 aut |
| 700 | 1 | a Santos, C. N.u Nova University of Lisbon, Portugal4 aut |
| 710 | 2 | a Chalmers tekniska högskolab Teknologian Tutkimuskeskus (VTT)4 org |
| 773 | 0 | t Comprehensive Reviews in Food Science and Food Safetyd : Wileyg 13:4, s. 413-436q 13:4<413-436x 1541-4337 |
| 856 | 4 | u http://publications.lib.chalmers.se/records/fulltext/200688/local_200688.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://publications.lib.chalmers.se/records/fulltext/200688/local_200688.pdf |
| 856 | 4 8 | u https://doi.org/10.1111/1541-4337.12081 |
| 856 | 4 8 | u https://research.chalmers.se/publication/200688 |
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