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Ice-Age Climate Ada...
Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity
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- Gossmann, Toni I. (author)
- Universität Bielefeld,Bielefeld University,University of Sheffield
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- Shanmugasundram, Achchuthan (author)
- The Francis Crick Institute,University of Liverpool
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- Börno, Stefan (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Duvaux, Ludovic (author)
- Université de Bordeaux,University of Bordeaux,Universite d'Angers,University of Angers
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- Lemaire, Christophe (author)
- Universite d'Angers,University of Angers
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- Kuhl, Heiner (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Klages, Sven (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Roberts, Lee D. (author)
- University Of Cambridge,University of Leeds
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- Schade, Sophia (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Gostner, Johanna M. (author)
- Medizinische Universität Innsbruck,Medical University of Innsbruck
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- Hildebrand, Falk (author)
- European Molecular Biology Laboratory,Earlham Institute
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- Vowinckel, Jakob (author)
- University Of Cambridge
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Bichet, Coraline (author)
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- Mülleder, Michael (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge
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- Calvani, Enrica (author)
- University Of Cambridge,The Francis Crick Institute
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- Zelezniak, Aleksej, 1984 (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Griffin, Julian L. (author)
- University Of Cambridge
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- Bork, Peer (author)
- Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine,European Molecular Biology Laboratory
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- Allaine, Dominique (author)
- Université de Lyon
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- Cohas, Aurélie (author)
- Université de Lyon
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- Welch, John J. (author)
- University Of Cambridge
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- Timmermann, Bernd (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Ralser, M. (author)
- Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge,The Francis Crick Institute
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 29:10, s. 1712-1720.e7
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https://doi.org/10.1...
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Abstract
Subject headings
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- © 2019 The Author(s) Some species responded successfully to prehistoric changes in climate [1, 2], while others failed to adapt and became extinct [3]. The factors that determine successful climate adaptation remain poorly understood. We constructed a reference genome and studied physiological adaptations in the Alpine marmot (Marmota marmota), a large ground-dwelling squirrel exquisitely adapted to the “ice-age” climate of the Pleistocene steppe [4, 5]. Since the disappearance of this habitat, the rodent persists in large numbers in the high-altitude Alpine meadow [6, 7]. Genome and metabolome showed evidence of adaptation consistent with cold climate, affecting white adipose tissue. Conversely, however, we found that the Alpine marmot has levels of genetic variation that are among the lowest for mammals, such that deleterious mutations are less effectively purged. Our data rule out typical explanations for low diversity, such as high levels of consanguineous mating, or a very recent bottleneck. Instead, ancient demographic reconstruction revealed that genetic diversity was lost during the climate shifts of the Pleistocene and has not recovered, despite the current high population size. We attribute this slow recovery to the marmot's adaptive life history. The case of the Alpine marmot reveals a complicated relationship between climatic changes, genetic diversity, and conservation status. It shows that species of extremely low genetic diversity can be very successful and persist over thousands of years, but also that climate-adapted life history can trap a species in a persistent state of low genetic diversity. Despite being highly abundant and well adapted, Gossmann et al. report that the Alpine marmot is among the least genetically diverse animal species. The low diversity is found to be the consequence of consecutive, climate-related events, including long-term extreme niche adaptation, that also greatly retarded the recovery of its genetic diversity.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Klimatforskning (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Climate Research (hsv//eng)
Keyword
- climate adaptation
- migration
- low genetic diversity
- lipidomics
- reference genome
- pleistocene
- large population size
- Alpine marmot
- ice age
- NUMT
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Gossmann, Toni I ...
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Shanmugasundram, ...
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Börno, Stefan
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Duvaux, Ludovic
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Lemaire, Christo ...
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Kuhl, Heiner
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show more...
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Klages, Sven
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Roberts, Lee D.
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Schade, Sophia
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Gostner, Johanna ...
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Hildebrand, Falk
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Vowinckel, Jakob
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Bichet, Coraline
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Mülleder, Michae ...
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Calvani, Enrica
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Zelezniak, Aleks ...
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Griffin, Julian ...
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Bork, Peer
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Allaine, Dominiq ...
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Cohas, Aurélie
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Welch, John J.
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Timmermann, Bern ...
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Ralser, M.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Ecology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Climate Research
- Articles in the publication
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Current Biology
- By the university
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Chalmers University of Technology
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Royal Institute of Technology