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Transcriptional Con...
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
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- Marques, Sueli (author)
- Karolinska Institutet
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- van Bruggen, David (author)
- Karolinska Institutet
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- Vanichkina, Darya Pavlovna (author)
- The University of Sydney,Univ Sydney, Centenary Inst, Gene & Stem Cell Therapy Program, Camperdown, NSW 2050, Australia;Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4067, Australia
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- Floriddia, Elisa Mariagrazia (author)
- Karolinska Institutet
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- Munguba, Hermany (author)
- Karolinska Institutet
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- Wigge, Leif, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Giacomello, Stefania (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Box 1031, S-17121 Solna, Sweden
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- Falcão, Ana Mendanha (author)
- Karolinska Institutet
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- Meijer, Mandy (author)
- Karolinska Institutet
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- Björklund, Åsa K. (author)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Hjerling-Leffler, Jens (author)
- Karolinska Institutet
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- Taft, Ryan James (author)
- University of Queensland,Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4067, Australia;Illumina Inc, San Diego, CA 92122 USA
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- Castelo-Branco, Gonçalo (author)
- Karolinska Institutet
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- Väremo, Leif (author)
- Chalmers Univ Technol, Dept Biol & Biol Engn, Sci Life Lab, Kemivagen 10, S-41296 Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Developmental Cell. - : Elsevier BV. - 1878-1551 .- 1534-5807. ; 46:4, s. 504-517
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Abstract
Subject headings
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- Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- transcription factors
- single-cell RNA-seq
- platelet-derived growth factor receptor alpha
- oligodendrocyte precursor cell
- myelin
- neural progenitors
- transcriptomics
- neural development
- pericyte
- oligodendrocyte
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Marques, Sueli
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van Bruggen, Dav ...
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Vanichkina, Dary ...
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Floriddia, Elisa ...
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Munguba, Hermany
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Wigge, Leif, 198 ...
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Giacomello, Stef ...
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Falcão, Ana Mend ...
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Meijer, Mandy
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Björklund, Åsa K ...
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Hjerling-Leffler ...
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Taft, Ryan James
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Castelo-Branco, ...
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Väremo, Leif
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Developmental Bi ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Developmental Ce ...
- By the university
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Chalmers University of Technology
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Stockholm University
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Uppsala University
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Karolinska Institutet