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Graphene-based sens...
Graphene-based sensor for detection of bacterial pathogens
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- Pandit, Santosh, 1987 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Mengyue, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Chen, Yanyan, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Rahimi, Shadi, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mokkapati, Venkata Raghavendra Subrahmanya Sar, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Merlo, Alessandra, 1992 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Yurgens, Avgust, 1959 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mijakovic, Ivan, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Danmarks Tekniske Universitet,Technical University of Denmark
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(creator_code:org_t)
- 2021-12-03
- 2021
- English.
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In: Sensors. - : MDPI AG. - 1424-8220. ; 21:23
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https://www.mdpi.com...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Microbial colonization to biomedical surfaces and biofilm formation is one of the key challenges in the medical field. Recalcitrant biofilms on such surfaces cause serious infections which are difficult to treat using antimicrobial agents, due to their complex structure. Early detection of microbial colonization and monitoring of biofilm growth could turn the tide by providing timely guidance for treatment or replacement of biomedical devices. Hence, there is a need for sensors, which could generate rapid signals upon bacterial colonization. In this study, we developed a simple prototype sensor based on pristine, non-functionalized graphene. The detection principle is a change in electrical resistance of graphene upon exposure to bacterial cells. Without functionalization with specific receptors, such sensors cannot be expected to be selective to certain bacteria. However, we demonstrated that two different bacterial species can be detected and differentiated by our sensor due to their different growth dynamics, adherence pattern, density of adhered bacteria and microcolonies formation. These distinct behaviors of tested bacteria depicted distinguishable pattern of resistance change, resistance versus gate voltage plot and hysteresis effect. This sensor is simple to fabricate, can easily be miniaturized, and can be effective in cases when precise identification of species is not needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Staphylococcus epidermidis
- Graphene
- Sensors
- Biofilms
- Pseudomonas aeruginosa
Publication and Content Type
- art (subject category)
- ref (subject category)
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Pandit, Santosh, ...
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Li, Mengyue, 198 ...
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Chen, Yanyan, 19 ...
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Rahimi, Shadi, 1 ...
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Mokkapati, Venka ...
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Merlo, Alessandr ...
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Yurgens, Avgust, ...
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Mijakovic, Ivan, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Sensors
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Chalmers University of Technology