Search: onr:"swepub:oai:research.chalmers.se:2c70f3f0-6ad9-4ba1-97c7-1cb7f67d10df" >
Stratification of p...
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
-
- Li, Xiangyu (author)
- KTH,Science for Life Laboratory, SciLifeLab,Bash Biotech Inc, 600 West Broadway,Suite 700, San Diego, CA 92101 USA
-
- Kim, Woonghee (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Juszczak, Kajetan (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
show more...
-
- Arif, Muhammad (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Sato, Yusuke (author)
- University of Tokyo, Japan,Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Dept Pathol & Tumor Biol, Kyoto 6068501, Japan.;Univ Tokyo, Grad Sch Med, Dept Urol, Tokyo 1138654, Japan.
-
- Kume, Haruki (author)
- University of Tokyo, Japan,Univ Tokyo, Grad Sch Med, Dept Urol, Tokyo 1138654, Japan.
-
- Ogawa, Seishi (author)
- Karolinska Institutet,Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Dept Pathol & Tumor Biol, Kyoto 6068501, Japan.;Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med, S-17177 Stockholm, Sweden.
-
- Turkez, Hasan (author)
- Atatürk Üniversitesi,Atatürk University,Ataturk Univ, Fac Med, Dept Med Biol, TR-25240 Erzurum, Turkey.
-
- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
-
- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII),Chalmers Univ Technol, Dept Biol & Biol Engn, S-41296 Gothenburg, Sweden.;BioInnovat Inst, DK-2200 Copenhagen N, Denmark.
-
- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Zhang, C. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Zhengzhou Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Adv Drug Preparat Technol, Zhengzhou 450001, Peoples R China.
-
- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
-
In: iScience. - : Elsevier BV. - 2589-0042. ; 24:7
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
http://www.cell.com/...
-
https://doi.org/10.1...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment. Here, we applied a systems biology approach to stratify ccRCC into three molecular subtypes with different mRNA expression patterns and prognosis of patients. Further, we developed a set of biomarkers that could robustly classify the patients into each of the three subtypes and predict the prognosis of patients. Then, we reconstructed subtype-specific metabolic models and performed essential gene analysis to identify the potential drug targets. We identified four drug targets, including SOAT1, CRLS1, and ACACB, essential in all the three subtypes and GPD2, exclusively essential to subtype 1. Finally, we repositioned mitotane, an FDA-approved SOAT1 inhibitor, to treat ccRCC and showed that it decreased tumor cell viability and inhibited tumor cell growth based on in vitro experiments.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Keyword
- bioinformatics
- systems biology
- cancer systems biology
- omics
- bioinformatics
- cancer systems biology
- omics
- systems biology
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
iScience
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Li, Xiangyu
-
Kim, Woonghee
-
Juszczak, Kajeta ...
-
Arif, Muhammad
-
Sato, Yusuke
-
Kume, Haruki
-
show more...
-
Ogawa, Seishi
-
Turkez, Hasan
-
Borén, Jan, 1963
-
Nielsen, Jens B, ...
-
Uhlén, Mathias
-
Zhang, C.
-
Mardinoglu, Adil ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
- Articles in the publication
-
iScience
- By the university
-
Chalmers University of Technology
-
University of Gothenburg
-
Royal Institute of Technology
-
Karolinska Institutet