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Aborting meiosis ov...
Aborting meiosis overcomes hybrid sterility
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- Mozzachiodi, Simone (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Tattini, Lorenzo (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Llored, Agnès (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Irizar, Agurtzane (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Škofljanc, Neža (author)
- Université Côte d'Azur,University of Côte d'Azur
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- D’Angiolo, Melania (author)
- Université Côte d'Azur,University of Côte d'Azur
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- De Chiara, Matteo (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Barré, Benjamin P. (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Yue, Jia Xing (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Lutazi, Angela (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Loeillet, Sophie (author)
- PSL University Paris
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- Laureau, Raphaelle (author)
- PSL University Paris
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- Marsit, Souhir (author)
- PSL University Paris,Université de Montpellier,University of Montpellier
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- Stenberg, Simon (author)
- Göteborgs universitet,University of Gothenburg
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Albaud, Benoit (author)
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- Persson, Karl, 1988 (author)
- Göteborgs universitet,University of Gothenburg
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- Legras, Jean-Luc (author)
- Université de Montpellier,University of Montpellier
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- Dequin, Sylvie (author)
- Université de Montpellier,University of Montpellier
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- Warringer, Jonas, 1973 (author)
- Göteborgs universitet,University of Gothenburg
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- Nicolas, Alain (author)
- PSL University Paris
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- Liti, Gianni (author)
- Université Côte d'Azur,University of Côte d'Azur
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2020
- 2020
- English.
- Related links:
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https://www.biorxiv....
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Hybrids between species or diverged lineages contain fundamentally novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explored to what extent and how an aborted meiosis followed by a return-to-growth (RTG) promotes recombination across a panel of 20 yeast diploid backgrounds with different genomic structures and levels of sterility. Genome analyses of 284 clones revealed that RTG promoted recombination and generated extensive regions of loss-ofheterozygosity in sterile hybrids with either a defective meiosis or a heavily rearranged karyotype, whereas RTG recombination was reduced by high sequence divergence between parental subgenomes. The RTG recombination preferentially occurred in regions with local sequence homology and in meiotic recombination hotspots. The loss-of-heterozygosity had a profound impact on sexual and asexual fitness, and enabled genetic mapping of phenotypic differences in sterile lineages where linkage or association analyses failed. We propose that RTG gives sterile hybrids access to a natural route for genome recombination and adaptation.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- vet (subject category)
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To the university's database
- By the author/editor
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Mozzachiodi, Sim ...
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Tattini, Lorenzo
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Llored, Agnès
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Irizar, Agurtzan ...
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Škofljanc, Neža
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D’Angiolo, Melan ...
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show more...
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De Chiara, Matte ...
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Barré, Benjamin ...
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Yue, Jia Xing
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Lutazi, Angela
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Loeillet, Sophie
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Laureau, Raphael ...
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Marsit, Souhir
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Stenberg, Simon
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Albaud, Benoit
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Persson, Karl, 1 ...
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Legras, Jean-Luc
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Dequin, Sylvie
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Warringer, Jonas ...
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Nicolas, Alain
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Liti, Gianni
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- By the university
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Chalmers University of Technology