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STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

Sütt, Silva (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Cansby, Emmelie, 1984 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Paul, Alexandra, 1988 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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Amrutkar, Manoj (author)
Universitetet i Oslo,University of Oslo
Nuñez-Durán, Esther (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Kulkarni, Nagaraj M. (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Ståhlman, Marcus, 1975 (author)
Borén, Jan (author)
Laurencikiene, Jurga (author)
Karolinska Institutet
Howell, Brian W. (author)
State University of New York Upstate Medical University
Enerbäck, Sven, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
Mahlapuu, Margit (author)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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 (creator_code:org_t)
2018
2018
English.
In: Journal of Endocrinology. - 1479-6805 .- 0022-0795. ; 238:3, s. 187-202
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Whole-body energy homeostasis at over-nutrition critically depends on how well adipose tissue remodels in response to excess calories. We recently identified serine/ threonine protein kinase (STK)25 as a critical regulator of ectopic lipid storage in non-adipose tissue and systemic insulin resistance in the context of nutritional stress. Here, we investigated the role of STK25 in regulation of adipose tissue dysfunction in mice challenged with a high-fat diet. We found that overexpression of STK25 in high-fat-fed mice resulted in impaired mitochondrial function and aggravated hypertrophy, inflammatory infiltration and fibrosis in adipose depots. Reciprocally, Stk25-knockout mice displayed improved mitochondrial function and were protected against diet-induced excessive fat storage, meta-inflammation and fibrosis in brown and white adipose tissues. Furthermore, in rodent HIB-1B cell line, STK25 depletion resulted in enhanced mitochondrial activity and consequently, reduced lipid droplet size, demonstrating an autonomous action for STK25 within adipocytes. In summary, we provide the first evidence for a key function of STK25 in controlling the metabolic balance of lipid utilization vs lipid storage in brown and white adipose depots, suggesting that repression of STK25 activity offers a potential strategy for establishing healthier adipose tissue in the context of chronic exposure to dietary lipids.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Oxidative stress
Brown adipose tissue
White adipose tissue
Lipid metabolism
Brown adipose tissue
Lipid metabolism
Oxidative stress
White adipose tissue

Publication and Content Type

art (subject category)
ref (subject category)

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