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Search: onr:"swepub:oai:research.chalmers.se:32ce0912-aa0e-4245-8bbb-522589d09de1" > Tissue-specific tra...

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  • Mazzurana, LucaKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (author)

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-08
  • Springer Science and Business Media LLC,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:32ce0912-aa0e-4245-8bbb-522589d09de1
  • https://doi.org/10.1038/s41422-020-00445-xDOI
  • https://research.chalmers.se/publication/521969URI
  • https://lup.lub.lu.se/record/009c0123-8e47-4fc7-949e-fd2da1a6f9e8URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450121URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145614784URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues. Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs, and signatures of tissue-residency, activation and modified metabolism in colon and lung ILCs. Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets. In the lung we identified both CRTH2+ and CRTH2− ILC2 with lung-specific signatures, which could be recapitulated by alarmin-exposure of circulating ILC2. Finally, we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells, revealing a subset of potentially immature ILCs with TCR-δ rearrangement. Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans, with implications for disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Czarnewski, PauloStockholm University,Stockholm Univ, Natl Bioinformat Infrastruct Sweden, Sci Life Lab, Dept Biochem & Biophys, Solna, Sweden. (author)
  • Jonsson, Viktor,1987Chalmers University of Technology,Chalmers Univ Technol, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Sci Life Lab, Gothenburg, Sweden.(Swepub:cth)jonssonv (author)
  • Wigge, Leif,1986Chalmers University of Technology,Chalmers Univ Technol, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Sci Life Lab, Gothenburg, Sweden.(Swepub:cth)varemo (author)
  • Ringnér, MarkusLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science,Lund Univ, Natl Bioinformat Infrastruct Sweden, Dept Biol, Sci Life Lab, Lund, Sweden.(Swepub:lu)thep-mri (author)
  • Williams, Teresa C.Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (author)
  • Ravindran, AvinashKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Karolinska Univ Hosp, Immunol & Allergy Unit, Dept Med Solna,Dept Clin Immunol & Transfus Med, Stockholm, Sweden. (author)
  • Björklund, Åsa K.Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Molekylär evolution(Swepub:uu)asbjo172 (author)
  • Säfholm, JesperKarolinska Institutet,Karolinska Institute,Karolinska Inst, Ctr Allergy Res, Inst Environm Med, Stockholm, Sweden. (author)
  • Nilsson, GunnarKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Karolinska Univ Hosp, Immunol & Allergy Unit, Dept Med Solna,Dept Clin Immunol & Transfus Med, Stockholm, Sweden. (author)
  • Dahlén, Sven ErikKarolinska Institutet,Karolinska Institute,Karolinska Inst, Ctr Allergy Res, Inst Environm Med, Stockholm, Sweden. (author)
  • Orre, Ann CharlotteKarolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Div Thorac Surg, Stockholm, Sweden. (author)
  • Al-Ameri, MamdohKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Div Thorac Surg, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden. (author)
  • Höög, CharlotteKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med Solna, Stockholm, Sweden. (author)
  • Hedin, CharlotteKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Gastroenterol Dermatovenereol & Rheumato, Div Gastroenterol, Stockholm, Sweden. (author)
  • Szczegielniak, SylwesterKarolinska Institutet (author)
  • Almer, SvenKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Gastroenterol Dermatovenereol & Rheumato, Div Gastroenterol, Stockholm, Sweden. (author)
  • Mjösberg, JennyKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (author)
  • Karolinska InstituteKarolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. (creator_code:org_t)

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  • In:Cell Research: Springer Science and Business Media LLC31:5, s. 554-5681748-78381001-0602

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