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Tissue-specific tra...
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Mazzurana, LucaKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
(author)
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-08
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Springer Science and Business Media LLC,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:research.chalmers.se:32ce0912-aa0e-4245-8bbb-522589d09de1
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https://doi.org/10.1038/s41422-020-00445-xDOI
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https://research.chalmers.se/publication/521969URI
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https://lup.lub.lu.se/record/009c0123-8e47-4fc7-949e-fd2da1a6f9e8URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450121URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145614784URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues. Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs, and signatures of tissue-residency, activation and modified metabolism in colon and lung ILCs. Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets. In the lung we identified both CRTH2+ and CRTH2− ILC2 with lung-specific signatures, which could be recapitulated by alarmin-exposure of circulating ILC2. Finally, we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells, revealing a subset of potentially immature ILCs with TCR-δ rearrangement. Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans, with implications for disease.
Subject headings and genre
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Czarnewski, PauloStockholm University,Stockholm Univ, Natl Bioinformat Infrastruct Sweden, Sci Life Lab, Dept Biochem & Biophys, Solna, Sweden.
(author)
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Jonsson, Viktor,1987Chalmers University of Technology,Chalmers Univ Technol, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Sci Life Lab, Gothenburg, Sweden.(Swepub:cth)jonssonv
(author)
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Wigge, Leif,1986Chalmers University of Technology,Chalmers Univ Technol, Natl Bioinformat Infrastruct Sweden, Dept Biol & Biol Engn, Sci Life Lab, Gothenburg, Sweden.(Swepub:cth)varemo
(author)
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Ringnér, MarkusLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science,Lund Univ, Natl Bioinformat Infrastruct Sweden, Dept Biol, Sci Life Lab, Lund, Sweden.(Swepub:lu)thep-mri
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Williams, Teresa C.Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
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Ravindran, AvinashKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Karolinska Univ Hosp, Immunol & Allergy Unit, Dept Med Solna,Dept Clin Immunol & Transfus Med, Stockholm, Sweden.
(author)
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Björklund, Åsa K.Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Molekylär evolution(Swepub:uu)asbjo172
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Säfholm, JesperKarolinska Institutet,Karolinska Institute,Karolinska Inst, Ctr Allergy Res, Inst Environm Med, Stockholm, Sweden.
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Nilsson, GunnarKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Karolinska Univ Hosp, Immunol & Allergy Unit, Dept Med Solna,Dept Clin Immunol & Transfus Med, Stockholm, Sweden.
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Dahlén, Sven ErikKarolinska Institutet,Karolinska Institute,Karolinska Inst, Ctr Allergy Res, Inst Environm Med, Stockholm, Sweden.
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Orre, Ann CharlotteKarolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Div Thorac Surg, Stockholm, Sweden.
(author)
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Al-Ameri, MamdohKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Div Thorac Surg, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
(author)
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Höög, CharlotteKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.
(author)
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Hedin, CharlotteKarolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Gastroenterol Dermatovenereol & Rheumato, Div Gastroenterol, Stockholm, Sweden.
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Szczegielniak, SylwesterKarolinska Institutet
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Almer, SvenKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Gastroenterol Dermatovenereol & Rheumato, Div Gastroenterol, Stockholm, Sweden.
(author)
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Mjösberg, JennyKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
(author)
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Karolinska InstituteKarolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden.
(creator_code:org_t)
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In:Cell Research: Springer Science and Business Media LLC31:5, s. 554-5681748-78381001-0602
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Mazzurana, Luca
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Czarnewski, Paul ...
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Jonsson, Viktor, ...
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Wigge, Leif, 198 ...
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Ringnér, Markus
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Al-Ameri, Mamdoh
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