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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03699naa a2200433 4500 | |
| 001 | oai:research.chalmers.se:3639f1bc-f797-44b7-90c9-54ba50faa1f8 | |
| 003 | SwePub | |
| 008 | 171007s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://research.chalmers.se/publication/2342302 URI |
| 024 | 7 | a https://doi.org/10.2147/ijn.s953752 DOI |
| 040 | a (SwePub)cth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Atefyekta, Saba,d 1987u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)sabaa |
| 245 | 1 0 | a Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release |
| 264 | c 2016-03 | |
| 264 | 1 | b Informa UK Limited,c 2016 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng |
| 653 | a antibacterial | |
| 653 | a drug delivery | |
| 653 | a mesoporous titania | |
| 653 | a implant coating | |
| 700 | 1 | a Ercan, B.u Northeastern University,Orta Doğu Teknik Üniversitesi,Middle East Technical University (METU)4 aut |
| 700 | 1 | a Karlsson, Johan,d 1984u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)karjoha |
| 700 | 1 | a Taylor, E.u Northeastern University4 aut |
| 700 | 1 | a Chung, S.u Northeastern University4 aut |
| 700 | 1 | a Webster, Thomasu Chalmers tekniska högskola,Chalmers University of Technology4 aut |
| 700 | 1 | a Andersson, Martin,d 1974u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)martina |
| 710 | 2 | a Chalmers tekniska högskolab Northeastern University4 org |
| 773 | 0 | t International journal of nanomedicined : Informa UK Limitedg 11, s. 977-990q 11<977-990x 1176-9114x 1178-2013 |
| 856 | 4 | u http://publications.lib.chalmers.se/records/fulltext/234230/local_234230.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u https://www.dovepress.com/getfile.php?fileID=29356 |
| 856 | 4 8 | u https://research.chalmers.se/publication/234230 |
| 856 | 4 8 | u https://doi.org/10.2147/ijn.s95375 |
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