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Graphene, other car...
Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design
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- Gazzi, Arianna (author)
- Basque Foundation for Science (Ikerbasque),Universita degli Studi di Trieste,University of Trieste
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- Fusco, Laura (author)
- Universita degli Studi di Trieste,University of Trieste,Basque Foundation for Science (Ikerbasque)
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- Orecchioni, Marco (author)
- Università degli Studi di Sassari,University of Sassari
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- Ferrari, Silvia (author)
- Università degli Studi di Sassari,University of Sassari
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Franzoni, Giulia (author)
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- Yan, J. Stephen (author)
- Rice University
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- Rieckher, Matthias (author)
- Universität zu Köln,University of Cologne
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- Peng, Guotao (author)
- Karolinska Institutet
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- Lucherelli, Matteo Andrea (author)
- Université de Strasbourg,University of Strasbourg
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- Anna Vacchi, Isabella (author)
- Université de Strasbourg,University of Strasbourg
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- Ngoc Do Quyen Chau, (author)
- Université de Strasbourg,University of Strasbourg
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- Criado, Alejandro (author)
- Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE
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- Istif, Akcan (author)
- Universita degli Studi di Trieste,University of Trieste
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- Mancino, Donato (author)
- Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE
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- Dominguez, Antonio (author)
- Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE
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- Eckert, Hagen (author)
- Technische Universität Dresden
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- Vazquez, Ester (author)
- Universidad de Castilla, La Mancha,University of Castilla, La Mancha
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- Da Ros, Tatiana (author)
- Universita degli Studi di Trieste,University of Trieste
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Nicolussi, Paola (author)
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- Palermo, Vincenzo, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Schumacher, Bjoern (author)
- Universität zu Köln,University of Cologne
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- Cuniberti, Gianaurelio (author)
- Technische Universität Dresden
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- Mai, Yiyong (author)
- Shanghai Jiao Tong University
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- Clementi, Cecilia (author)
- Rice University
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- Pasquali, Matteo (author)
- Rice University
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- Feng, Xinliang (author)
- Technische Universität Dresden
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- Kostarelos, Kostas (author)
- University of Manchester,Fundacio Institut Catala de Nanociencia i Nanotecnologia (ICN2),Catalan Institute of Nanoscience and Nanotechnology (ICN2)
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- Yilmazer, Acelya (author)
- Ankara Universitesi
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Bedognetti, Davide (author)
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- Fadeel, Bengt (author)
- Karolinska Institutet
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- Prato, Maurizio (author)
- Universita degli Studi di Trieste,University of Trieste,Basque Foundation for Science (Ikerbasque),Centro de Investigación Cooperativa en Biomateriales CIC biomaGUNE
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- Bianco, Alberto (author)
- Université de Strasbourg,University of Strasbourg
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- Delogu, Lucia Gemma (author)
- Università degli Studi di Sassari,University of Sassari,Università Degli Studi di Padova,University of Padua
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(creator_code:org_t)
- 2020-07-13
- 2020
- English.
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In: JPhys Materials. - : IOP Publishing. - 2515-7639. ; 3:3
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (e.g. structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties has been missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.
Subject headings
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Keyword
- nanotoxicology
- carbon nanotubes
- single cell mass cytometry
- systems biology
- graphene
- nanomedicine
- nanosafety
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Gazzi, Arianna
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Fusco, Laura
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Orecchioni, Marc ...
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Ferrari, Silvia
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Franzoni, Giulia
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Yan, J. Stephen
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show more...
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Rieckher, Matthi ...
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Peng, Guotao
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Lucherelli, Matt ...
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Anna Vacchi, Isa ...
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Ngoc Do Quyen Ch ...
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Criado, Alejandr ...
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Istif, Akcan
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Mancino, Donato
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Dominguez, Anton ...
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Eckert, Hagen
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Vazquez, Ester
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Da Ros, Tatiana
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Nicolussi, Paola
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Palermo, Vincenz ...
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Schumacher, Bjoe ...
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Cuniberti, Giana ...
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Mai, Yiyong
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Clementi, Cecili ...
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Pasquali, Matteo
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Feng, Xinliang
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Kostarelos, Kost ...
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Yilmazer, Acelya
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Bedognetti, Davi ...
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Fadeel, Bengt
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Prato, Maurizio
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Bianco, Alberto
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Delogu, Lucia Ge ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Materials Chemis ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Condensed Matter ...
- Articles in the publication
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JPhys Materials
- By the university
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Chalmers University of Technology
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Karolinska Institutet