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Study for Improving...
Study for Improving Maternal Pregnancy And Child ouTcomes (IMPACT): a study protocol for a Swedish prospective multicentre cohort study
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- Bergman, Lina, 1982 (author)
- Uppsala universitet,Uppsala University,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrenska Academy,Klinisk obstetrik
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- Sandström, Anna (author)
- Uppsala universitet,Uppsala University,Karolinska Institutet,Klinisk obstetrik,Clinical Epidemiology Division, Department of Medicine, Karolinska Institute, Stockholm, Stockholm County, Sweden
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- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrenska University Hospital
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- Hansson, Stefan (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences Lund, Obstetrics and Gynecology, Lunds Universitet, Lund, Sweden; Department of Obstetrics and Gynecology, Skåne University Hospital Lund, Lund, Skåne, Sweden
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- Lindgren, Peter (author)
- Karolinska Institutet,Karolinska University Hospital,Center for Fetal Medicine, Karolinska Universitetssjukhuset, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Stockholm County, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Uppsala University,Klinisk kemi
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- Imberg, Henrik, 1991 (author)
- Chalmers University of Technology,Department of Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden
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- Conner, Peter (author)
- Karolinska Institutet,Department of Women's and Children's Health, Karolinska Institute, Stockholm, Stockholm County, Sweden
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- Kublickas, Marius (author)
- Karolinska Institutet,Karolinska University Hospital,Center for Fetal Medicine, Karolinska Universitetssjukhuset, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Stockholm County, Sweden
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- Carlsson, Ylva, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden,Sahlgrenska University Hospital
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- Wikström, Anna-Karin, 1965- (author)
- Uppsala universitet,Uppsala University,Klinisk obstetrik
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(creator_code:org_t)
- 2020-09-23
- 2020
- English.
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In: BMJ Open. - : BMJ. - 2044-6055 .- 2044-6055. ; 10:9, s. e033851-e033851
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Abstract
Subject headings
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- Introduction First-trimester pregnancy risk evaluation facilitates individualised antenatal care, as well as application of preventive strategies for pre-eclampsia or birth of a small for gestational age infant. A range of early intervention strategies in pregnancies identified as high risk at the end of the first trimester has been shown to decrease the risk of preterm pre-eclampsia (<37 gestational weeks). The aim of this project is to create the Improving Maternal Pregnancy And Child ouTcomes (IMPACT) database; a nationwide database with individual patient data, including predictors recorded at the end of the first trimester and later pregnancy outcomes, to identify women at high risk of pre-eclampsia. A second aim is to link the IMPACT database to a biobank with first-trimester blood samples. Methods and analysis This is a Swedish prospective multicentre cohort study. Women are included between the 11th and 14th weeks of pregnancy. At inclusion, pre-identified predictors are retrieved by interviews and medical examinations. Blood samples are collected and stored in a biobank. Additional predictors and pregnancy outcomes are retrieved from the Swedish Pregnancy Register. Inclusion in the study began in November 2018 with a targeted sample size of 45 000 pregnancies by end of 2021. Creation of a new risk prediction model will then be developed, validated and implemented. The database and biobank will enable future research on prediction of various pregnancy-related complications. Ethics and dissemination Confidentiality aspects such as data encryption and storage comply with the General Data Protection Regulation and with ethical committee requirements. This study has been granted national ethical approval by the Swedish Ethical Review Authority (Uppsala 2018-231) and national biobank approval at Uppsala Biobank (18237 2 2018 231). Results from the current as well as future studies using information from the IMPACT database will be published in peer-reviewed journals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- first-trimester screening
- placental growth factor
- preeclampsia
- mean arterial pressure
- first-trimester screening
- mean arterial pressure
- placental growth factor
- preeclampsia
Publication and Content Type
- art (subject category)
- ref (subject category)
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Bergman, Lina, 1 ...
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Sandström, Anna
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Jacobsson, Bo, 1 ...
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Hansson, Stefan
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Lindgren, Peter
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Larsson, Anders
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Imberg, Henrik, ...
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Conner, Peter
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Kublickas, Mariu ...
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Carlsson, Ylva, ...
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Wikström, Anna-K ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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BMJ Open
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Chalmers University of Technology
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University of Gothenburg
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Lund University
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Uppsala University
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Karolinska Institutet