Electrically Switchable Polymer Brushes for Protein Capture and Release in Biological Environments**

Ferrand-Drake Del Castillo, Gustav,1990Chalmers tekniska högskola,Chalmers University of Technology (author)

Interfaces functionalized with polymers are known for providing excellent resistance towards biomolecular adsorption and for their ability to bind high amounts of protein while preserving their structure. However, making an interface that switches between these two states has proven challenging and concepts to date rely on changes in the physiochemical environment, which is static in biological systems. Here we present the first interface that can be electrically switched between a high-capacity (>1 μg cm−2) multilayer protein binding state and a completely non-fouling state (no detectable adsorption). Switching is possible over multiple cycles without any regeneration. Importantly, switching works even when the interface is in direct contact with biological fluids and a buffered environment. The technology offers many applications such as zero fouling on demand, patterning or separation of proteins as well as controlled release of biologics in a physiological environment, showing high potential for future drug delivery in vivo.

Kyriakidou, MariaCardiff University (author)
Adali, Zeynep (author)
Xiong, Kunli,1987Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)kunil (author)
Hailes, Rebekah,1992Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)rebekah (author)
Dahlin, Andreas,1980Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)adahlin (author)
Chalmers tekniska högskolaCardiff University (creator_code:org_t)

By the author/editor: Ferrand-Drake De ...; Kyriakidou, Mari ...; Adali, Zeynep; Xiong, Kunli, 19 ...; Hailes, Rebekah, ...; Dahlin, Andreas, ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biophysics

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

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