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Metastatic triple n...
Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures
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- Roshanzamir, Fariba, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,University of Tehran
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- Robinson, Jonathan, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Cook, Daniel John, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Karimi-Jafari, Mohammad Hossein (author)
- University of Tehran
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- Nielsen, Jens B, 1962 (author)
- BioInnovation Institute (BII),Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2022-08-22
- 2022
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:35
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Abstract
Subject headings
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- Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in different organs as in the original primary tumor. However, studies of metastasis are often limited to a comparison of metastatic tumors with primary tumors of their origin, and little is known about the adaptation to the local environment of the metastatic sites. We therefore used transcriptomic data and metabolic network analyses to investigate whether metastatic tumors adapt their metabolism to the metastatic site and found that metastatic tumors adopt a metabolic signature with some similarity to primary tumors of their destinations. The extent of adaptation, however, varies across different organs, and metastatic tumors retain metabolic signatures associated with TNBC. Our findings suggest that a combination of anti-metastatic approaches and metabolic inhibitors selected specifically for different metastatic sites, rather than solely targeting TNBC primary tumors, may constitute a more effective treatment approach.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- gene expression
- systems biology
- metastasis
- triple negative breast cancer
- genome-scale metabolic models
Publication and Content Type
- art (subject category)
- ref (subject category)
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