Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

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Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

Hantke, Max Felix (author): Uppsala universitet,Molekylär biofysik,Univ Oxford, Dept Chem, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England

Bielecki, Johan, 1982 (author): Uppsala universitet,Molekylär biofysik,European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany

Kulyk, Olena (author): Czech Academy of Sciences,Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic

Westphal, Daniel (author): Uppsala universitet,Molekylär biofysik

Larsson, Daniel S. D. (author): Uppsala universitet,Molekylär biofysik

Svenda, Martin (author): Uppsala universitet,Molekylär biofysik

Reddy, Hemanth K.N. (author): Uppsala universitet,Molekylär biofysik

Kirian, Richard A. (author): Arizona State University,Arizona State Univ, Dept Phys, 550 E Tyler Dr, Tempe, AZ 85287 USA

Andreasson, Jakob, 1975 (author): Uppsala universitet,Molekylär biofysik,Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic;Chalmers Univ Technol, Dept Phys, Condensed Matter Phys, Gothenburg, Sweden

Hajdu, Janos (author): Uppsala universitet,Molekylär biofysik,Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic

Maia, Filipe R.N.C. (author): Uppsala universitet,Molekylär biofysik,Lawrence Berkeley Natl Lab, NERSC, Berkeley, CA USA

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2018
2018
English.
In: IUCrJ. - 2052-2525. ; 5, s. 673-680

Related links:: https://research.cha... (primary) (free); show more...; https://doi.org/10.1...; https://uu.diva-port... (primary) (Raw object); https://research.cha...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Ultra-bright femtosecond X-ray pulses generated by X-ray free-electron lasers (XFELs) can be used to image high-resolution structures without the need for crystallization. For this approach, aerosol injection has been a successful method to deliver 70-2000 nm particles into the XFEL beam efficiently and at low noise. Improving the technique of aerosol sample delivery and extending it to single proteins necessitates quantitative aerosol diagnostics. Here a lab-based technique is introduced for Rayleigh-scattering microscopy allowing us to track and size aerosolized particles down to 40 nm in diameter as they exit the injector. This technique was used to characterize the 'Uppsala injector', which is a pioneering and frequently used aerosol sample injector for XFEL single-particle imaging. The particle-beam focus, particle velocities, particle density and injection yield were measured at different operating conditions. It is also shown how high particle densities and good injection yields can be reached for large particles (100-500 nm). It is found that with decreasing particle size, particle densities and injection yields deteriorate, indicating the need for different injection strategies to extend XFEL imaging to smaller targets, such as single proteins. This work demonstrates the power of Rayleigh-scattering microscopy for studying focused aerosol beams quantitatively. It lays the foundation for lab-based injector development and online injection diagnostics for XFEL research. In the future, the technique may also find application in other fields that employ focused aerosol beams, such as mass spectrometry, particle deposition, fuel injection and three-dimensional printing techniques.

Subject headings

NATURVETENSKAP -- Fysik -- Acceleratorfysik och instrumentering (hsv//swe)
NATURAL SCIENCES -- Physical Sciences -- Accelerator Physics and Instrumentation (hsv//eng)
NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)

Keyword

Uppsala injectors
nanoparticles
XFELs
aerosol injection
Rayleigh scattering

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By the author/editor: Hantke, Max Feli ...; Bielecki, Johan, ...; Kulyk, Olena; Westphal, Daniel; Larsson, Daniel ...; Svenda, Martin; show more...; Reddy, Hemanth K ...; Kirian, Richard ...; Andreasson, Jako ...; Hajdu, Janos; Maia, Filipe R.N ...; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Accelerator Phys ...

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Atom and Molecul ...

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Other Physics To ...

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Physical Chemist ...

Articles in the publication: IUCrJ

By the university: Chalmers University of Technology; Uppsala University

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