Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy

• The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

neuropsychology

multiple sclerosis

optic neuritis

magnetic resonance imaging

Clinically isolated syndrome

cohort

Clinically isolated syndrome; multiple sclerosis; cohort; optic neuritis; neuropsychology; magnetic resonance imaging

Publication and Content Type

art (subject category)

ref (subject category)