Search: onr:"swepub:oai:research.chalmers.se:425afcd6-e708-4bf1-b77b-1a428874ed9c" >
BioMet Toolbox: gen...
BioMet Toolbox: genome-wide analysis of metabolism
-
- Cvijovic, Marija, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Olivares Hernandez, Roberto, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Ågren, Rasmus, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
show more...
-
- Dahr, Niklas, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Vongsangnak, Wanwipa, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Patil, K. R. (author)
- Danmarks Tekniske Universitet,Technical University of Denmark
-
- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
show less...
-
(creator_code:org_t)
- 2010-05-18
- 2010
- English.
-
In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 38:SUPPL. 2, s. W144-W149
- Related links:
-
http://publications.... (primary) (free)
-
show more...
-
https://academic.oup...
-
https://doi.org/10.1...
-
https://research.cha...
-
show less...
Abstract
Subject headings
Close
- The rapid progress of molecular biology tools for directed genetic modifications, accurate quantitative experimental approaches, high-throughput measurements, together with development of genome sequencing has made the foundation for a new area of metabolic engineering that is driven by metabolic models. Systematic analysis of biological processes by means of modelling and simulations has made the identification of metabolic networks and prediction of metabolic capabilities under different conditions possible. For facilitating such systemic analysis, we have developed the BioMet Toolbox, a web-based resource for stoichiometric analysis and for integration of transcriptome and interactome data, thereby exploiting the capabilities of genome-scale metabolic models. The BioMet Toolbox provides an effective user-friendly way to perform linear programming simulations towards maximized or minimized growth rates, substrate uptake rates and metabolic production rates by detecting relevant fluxes, simulate single and double gene deletions or detect metabolites around which major transcriptional changes are concentrated. These tools can be used for high-throughput in silico screening and allows fully standardized simulations. Model files for various model organisms (fungi and bacteria) are included. Overall, the BioMet Toolbox serves as a valuable resource for exploring the capabilities of these metabolic networks. BioMet Toolbox is freely available at www.sysbio.se/BioMet/.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Keyword
- transcriptional regulation
- network
- reconstruction
- saccharomyces-cerevisiae
- fluxes
- models
- systems biology
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Cvijovic, Marija ...
-
Olivares Hernand ...
-
Ågren, Rasmus, 1 ...
-
Dahr, Niklas, 19 ...
-
Vongsangnak, Wan ...
-
Nookaew, Intawat ...
-
show more...
-
Patil, K. R.
-
Nielsen, Jens B, ...
-
show less...
- About the subject
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Industrial Biote ...
- Articles in the publication
-
Nucleic Acids Re ...
- By the university
-
Chalmers University of Technology