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CONTRIBUTION OF IND...
CONTRIBUTION OF INDIRECT EFFECTS TO CLUSTERED DAMAGE IN DNA IRRADIATED WITH PROTONS
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- Pachnerova Brabcová, Katerina, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Stepan, V. (author)
- Czech Academy of Sciences,Centre d'Etudes Nucleaires de Bordeaux Gradignan
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- Karamitros, M. (author)
- Centre d'Etudes Nucleaires de Bordeaux Gradignan
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- Karabin, M. (author)
- Vysoká škola chemicko-technologická v Praze,University of Chemistry and Technology, Prague
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- Dostalek, P. (author)
- Vysoká škola chemicko-technologická v Praze,University of Chemistry and Technology, Prague
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- Incerti, S. (author)
- Centre d'Etudes Nucleaires de Bordeaux Gradignan
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- Davidkova, M. (author)
- Czech Academy of Sciences
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- Sihver, Lembit, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2015-04-20
- 2015
- English.
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In: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 0144-8420 .- 1742-3406. ; 166:1-4, s. 44-48
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http://dx.doi.org/10...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Protons are the dominant particles both in galactic cosmic rays and in solar particle events and, furthermore, proton irradiation becomes increasingly used in tumour treatment. It is believed that complex DNA damage is the determining factor for the consequent cellular response to radiation. DNA plasmid pBR322 was irradiated at U120-M cyclotron with 30 MeV protons and treated with two Escherichia coli base excision repair enzymes. The yields of SSBs and DSBs were analysed using agarose gel electrophoresis. DNA has been irradiated in the presence of hydroxyl radical scavenger (coumarin-3-carboxylic acid) in order to distinguish between direct and indirect damage of the biological target. Pure scavenger solution was used as a probe for measurement of induced OH center dot radical yields. Experimental OH center dot radical yield kinetics was compared with predictions computed by two theoretical models-RADAMOL and Geant4-DNA. Both approaches use Geant4-DNA for description of physical stages of radiation action, and then each of them applies a distinct model for description of the pre-chemical and chemical stage.
Subject headings
- NATURVETENSKAP -- Fysik -- Subatomär fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Subatomic Physics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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