Sökning: onr:"swepub:oai:research.chalmers.se:4374837c-c785-485a-a11d-8a841838f49e" >
Screw motion of DNA...
Screw motion of DNA duplex during translocation through pore. I. Introduction of the coarse-grained model
-
- Starikov, Evgeni B. (författare)
- Karlsruher Institut für Technologie (KIT),Karlsruhe Institute of Technology (KIT),Technische Universität Dresden
-
- Hennig, D. (författare)
- Humboldt-Universität zu Berlin,Humboldt University of Berlin
-
Yamada, H. (författare)
-
visa fler...
-
- Gutierrez, R. (författare)
- Technische Universität Dresden
-
- Nordén, Bengt, 1945 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Cuniberti, G. (författare)
- Technische Universität Dresden
-
visa färre...
-
(creator_code:org_t)
- 2009
- 2009
- Engelska.
-
Ingår i: Biophysical Reviews and Letters. - 1793-0480. ; 4:3, s. 209-230
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://research.cha...
-
visa färre...
Abstract
Ämnesord
Stäng
- Based upon the structural properties of DNA duplexes and their counterion-water surrounding in solution, we have introduced here a screw model which may describe translocation of DNA duplexes through artificial nanopores of the proper diameter (where the DNA counterion-hydration shell can be intact) in a qualitatively correct way. This model represents DNA as a kind of "screw," whereas the counterion-hydration shell is a kind of "nut." Mathematical conditions for stable dynamics of the DNA screw model are investigated in detail. When an electrical potential is applied across an artificial membrane with a nanopore, the "screw" and "nut" begin to move with respect to each other, so that their mutual rotation is coupled with their mutual translation. As a result, there are peaks of electrical current connected with the mutual translocation of DNA and its counterion-hydration shell, if DNA is possessed of some non-regular base-pair sequence. The calculated peaks of current strongly resemble those observed in the pertinent experiments. An analogous model could in principle be applied to DNA translocation in natural DNA-protein complexes of biological interest, where the role of "nut" would be played by protein-tailored "channels." In such cases, the DNA screw model is capable of qualitatively explaining chemical-to-mechanical energy conversion in DNA-protein molecular machines via symmetry breaking in DNA-protein friction.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- DNA
- Screw-jack
- Screw and nut
- Screw
- Nanopore translocation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas