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Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk

Bodén, Stina (author)
Umeå universitet,Onkologi,Pediatrik,Umea Univ, Dept Diagnost & Intervent Oncol, Umea, Sweden.;Umea Univ, Dept Clin Sci Pediat, Umea, Sweden.
Zheng, Rui (author)
Uppsala universitet,Klinisk epidemiologi
Ribbenstedt, Anton, 1986 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden,Chalmers Univ Technol, Dept Life Sci, Gothenburg, Sweden.
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Landberg, Rikard, 1981 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden,Chalmers Univ Technol, Dept Life Sci, Gothenburg, Sweden.
Harlid, Sophia, 1978- (author)
Umeå universitet,Onkologi,Umea Univ, Dept Diagnost & Intervent Oncol, Umea, Sweden.
Vidman, Linda (author)
Umeå universitet,Onkologi,Umea Univ, Dept Diagnost & Intervent Oncol, Umea, Sweden.
Gunter, Marc (author)
International Agency for Research on Cancer (IARC),Imperial College of Science, Technology and Medicine,International Agency for Research On Cancer, Nutrition and Metabolism Section, Lyon Cedex 08, France; Cancer Epidemiology and Prevention Research Unit, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom,Int Agcy Res Canc, Nutr & Metab Sect, F-69372 Lyon, France.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, Canc Epidemiol & Prevent Res Unit, London, England.
Winkvist, Anna, 1962 (author)
Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Avdelningen för hållbar hälsa,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, Sustainable Hlth, Umea, Sweden.
Johansson, Ingegerd (author)
Umeå universitet,Kardiologi,Umea Univ, Dept Odontol, Sect Cariol, Umea, Sweden.
van Guelpen, Bethany (author)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi,Umea Univ, Dept Diagnost & Intervent Oncol, Umea, Sweden.;Umea Univ, Wallenberg Ctr Mol Med, Umea, Sweden.
Brunius, Carl, 1974 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden,Chalmers Univ Technol, Dept Life Sci, Gothenburg, Sweden.
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 (creator_code:org_t)
Springer Nature, 2024
2024
English.
In: Scientific Reports. - : Springer Nature. - 2045-2322 .- 2045-2322. ; 14:1
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We investigated data-driven and hypothesis-driven dietary patterns and their association to plasma metabolite profiles and subsequent colorectal cancer (CRC) risk in 680 CRC cases and individually matched controls. Dietary patterns were identified from combined exploratory/confirmatory factor analysis. We assessed association to LC–MS metabolic profiles by random forest regression and to CRC risk by multivariable conditional logistic regression. Principal component analysis was used on metabolite features selected to reflect dietary exposures. Component scores were associated to CRC risk and dietary exposures using partial Spearman correlation. We identified 12 data-driven dietary patterns, of which a breakfast food pattern showed an inverse association with CRC risk (OR per standard deviation increase 0.89, 95% CI 0.80–1.00, p = 0.04). This pattern was also inversely associated with risk of distal colon cancer (0.75, 0.61–0.96, p = 0.01) and was more pronounced in women (0.69, 0.49–0.96, p = 0.03). Associations between meat, fast-food, fruit soup/rice patterns and CRC risk were modified by tumor location in women. Alcohol as well as fruit and vegetables associated with metabolite profiles (Q2 0.22 and 0.26, respectively). One metabolite reflecting alcohol intake associated with increased CRC risk, whereas three metabolites reflecting fiber, wholegrain, and fruit and vegetables associated with decreased CRC risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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