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Protein-olive oil-i...
Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
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- Bharmoria, Pankaj, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Bisht, Meena (author)
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Gomes, Maria C. (author)
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Martins, Margarida (author)
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Neves, Márcia C. (author)
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Mano, João F. (author)
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- Bdikin, Igor (author)
- Universidade de Aveiro,University of Aveiro
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Coutinho, João A.P. (author)
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Ventura, Sónia P.M. (author)
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(creator_code:org_t)
- 2021-04-27
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 11:1, s. 9099-9099
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- Demethoxycurcumin
- Turmeric extract
- Curcumin
Publication and Content Type
- art (subject category)
- ref (subject category)
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