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- David, Florian,1981Chalmers tekniska högskola,Chalmers University of Technology (author)
A Perspective on Synthetic Biology in Drug Discovery and Development - Current Impact and Future Opportunities
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- Elsevier BV,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:research.chalmers.se:4954aa7d-4ed2-4156-b652-4ce55222dbab
- https://doi.org/10.1177/24725552211000669DOI
- https://research.chalmers.se/publication/523548URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline’s application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline’s contribution can further enhance the opportunities for the drug discovery and development value chain.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Maskinteknik Annan maskinteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Mechanical Engineering Other Mechanical Engineering hsv//eng
- NATURVETENSKAP Data- och informationsvetenskap Programvaruteknik hsv//swe
- NATURAL SCIENCES Computer and Information Sciences Software Engineering hsv//eng
- NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
- late-stage functionalization
- chassis organism
- drug discovery
- synthetic biology
- biofoundry
- CRISPR-Cas9
Added entries (persons, corporate bodies, meetings, titles ...)
- Davis, Andrew M.AstraZeneca AB (author)
- Gossing, Michael,1982AstraZeneca AB(Swepub:cth)gossing (author)
- Hayes, Martin A.AstraZeneca AB (author)
- Romero, ElviraAstraZeneca AB (author)
- Scott, Louis H.AstraZeneca AB (author)
- Wigglesworth, Mark J.AstraZeneca AB (author)
- Chalmers tekniska högskolaAstraZeneca AB (creator_code:org_t)
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- In:SLAS Discovery: Elsevier BV26:5, s. 581-6032472-55522472-5560
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