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Protein cohabitatio...
Protein cohabitation: long-term immunoglobulin G storage at room temperature
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- Bharmoria, Pankaj, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Dept Chem & Chem Engn, Kemivagen 4, S-41296 Gothenburg, Sweden.;ICMAB CSIC, Inst Mat Sci Barcelona, Barcelona 08193, Spain.
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- Ooi, Saik Ann (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
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- Cellini, Andrea (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
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- Tietze, Daniel, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
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- Maj, Michał (author)
- Uppsala universitet,Fysikalisk kemi,Strukturbiologi,Angstrom Lab, Dept Chem, Phys Chem, Lagerhyddsvagen 1, S-75120 Uppsala, Sweden.
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- Moth-Poulsen, Kasper, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Institut de Ciència de Materials de Barcelona (ICMAB-CSIC),Institute of Material Science of Barcelona (ICMAB),Institucio Catalana de Recerca i Estudis Avancats (ICREA),Catalan Institution for Research and Advanced Studies (ICREA),Universitat Politecnica de Catalunya,Polytechnic University of Catalonia,Chalmers Univ Technol, Dept Chem & Chem Engn, Kemivagen 4, S-41296 Gothenburg, Sweden.;ICMAB CSIC, Inst Mat Sci Barcelona, Barcelona 08193, Spain.;ICREA, Catalan Inst Res & Adv Studies, Pg Lluis Co 23, Barcelona, Spain.;Univ Politecn Cataluna, EEBE, Dept Chem Engn, Eduard Maristany 10-14, Barcelona 08019, Spain.
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- Tietze, Alesia A., 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 10, S-41296 Gothenburg, Sweden.
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- Royal Society of Chemistry, 2023
- 2023
- English.
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In: Journal of Materials Chemistry B. - : Royal Society of Chemistry. - 2050-750X .- 2050-7518. ; 11:24, s. 5400-5405
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Abstract
Subject headings
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- Long-term functional storage of therapeutic proteins at room temperature has been an eternal challenge. Inspired by the cellular cooperativity of proteins, we have taken a step forward to address this challenge by cohabitating Immunoglobulin G (IgG1) with a food protein gelatin in the solid-state at room temperature. Interestingly, IgG1 remained functionally active for a record 14 months revealed from the western-blot assay. Further quantification by HP-LC analysis showed 100% structural integrity of IgG1 with no degradation in the gelatin matrix during this period. The developed formulation has a direct application in oral medical nutrition therapy to cure gastrointestinal microbial infections. Also the strategy provides a robust energy economic alternative to the protein engineering methods for long-term functional storage of therapeutic proteins at room temperature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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