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Conformational effe...
Conformational effects of UV light on DNA origami
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- Chen, H. R. (author)
- Purdue University
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- Li, Ruixin (author)
- Purdue University
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- Li, Shiming, 1947 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Andreasson, Joakim, 1973 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Choi, J. H. (author)
- Purdue University
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(creator_code:org_t)
- 2017-01-20
- 2017
- English.
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In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 139:4, s. 1380-1383
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Abstract
Subject headings
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- The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects in the origami, nor do they significantly affect the hybridization capability. Instead, they help relieve the internal stress in the origami structure and restore it to the designed conformation. At high doses, staple dissociation increases which causes structural disintegration. Long-wavelength UV does not show any effect on origami conformation by itself. We show that this UV range can be used in conjunction with photoactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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