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Wurster fluidised-bed coating: Coarse-graining technique within CFD-DEM in conjunction with heat and mass transfer

Kjaer Jepsen, Philip, 1995 (author)
Chalmers tekniska högskola,Chalmers University of Technology
De Juan, Luis Martin (author)
AstraZeneca AB
Boje, Astrid, 1991 (author)
AstraZeneca AB
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Sarangi, Sohan (author)
AstraZeneca AB
Corswant, Christian von (author)
AstraZeneca AB
Sasic, Srdjan, 1968 (author)
Chalmers tekniska högskola,Chalmers University of Technology
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 (creator_code:org_t)
2024
2024
English.
In: Powder Technology. - 1873-328X .- 0032-5910. ; 443
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • In this study, we use a combined CFD-Discrete Element Method to assess predictive capabilities and numerical implications of a coarse-graining technique in Wurster fluidised-bed coaters. We investigated both hydrodynamics and heat and mass transfer and conducted simulations of a full three-phase system for the original and three coarse-grained systems, analysing velocity distributions, macroscopic solid stresses, moisture content and phase temperatures. We achieved a logarithmic simulation speed-up by aggregating up to 64 original particles into each coarse grain. This was accomplished while maintaining fidelity to the original CFD-DEM system in terms of reproducing with high accuracy macroscopic granular flow properties in different regions of a coater (drying, tube and bed regions). By integrating a liquid spray and humid air, we demonstrated that the phase temperatures were accurately predicted within the coarse-grained system, with a high capability of delivering liquid spray distributions with the same uniformity and drying. We also give arguments for choosing a certain degree of coarse-graining as a compromise between a desired reduction of computational costs and a trustworthy reproduction of granular-flow physics encountered in different regions of a Wurster bed. Our findings pave the way to using CFD-DEM to industrially-scaled Wurster-bed systems, which is currently unfeasible due to prohibitive computational costs.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering (hsv//eng)
NATURVETENSKAP  -- Fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Kemiteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Chemical Engineering (hsv//eng)

Keyword

Three-phase system
CFD-DEM
Liquid spray modelling
Coarse-graining technique
Granular flow regime characterisation
Wurster fluidised-bed coater

Publication and Content Type

art (subject category)
ref (subject category)

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