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Wurster fluidised-b...
Wurster fluidised-bed coating: Coarse-graining technique within CFD-DEM in conjunction with heat and mass transfer
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- Kjaer Jepsen, Philip, 1995 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- De Juan, Luis Martin (author)
- AstraZeneca AB
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- Boje, Astrid, 1991 (author)
- AstraZeneca AB
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- Sarangi, Sohan (author)
- AstraZeneca AB
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- Corswant, Christian von (author)
- AstraZeneca AB
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- Sasic, Srdjan, 1968 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Powder Technology. - 1873-328X .- 0032-5910. ; 443
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- In this study, we use a combined CFD-Discrete Element Method to assess predictive capabilities and numerical implications of a coarse-graining technique in Wurster fluidised-bed coaters. We investigated both hydrodynamics and heat and mass transfer and conducted simulations of a full three-phase system for the original and three coarse-grained systems, analysing velocity distributions, macroscopic solid stresses, moisture content and phase temperatures. We achieved a logarithmic simulation speed-up by aggregating up to 64 original particles into each coarse grain. This was accomplished while maintaining fidelity to the original CFD-DEM system in terms of reproducing with high accuracy macroscopic granular flow properties in different regions of a coater (drying, tube and bed regions). By integrating a liquid spray and humid air, we demonstrated that the phase temperatures were accurately predicted within the coarse-grained system, with a high capability of delivering liquid spray distributions with the same uniformity and drying. We also give arguments for choosing a certain degree of coarse-graining as a compromise between a desired reduction of computational costs and a trustworthy reproduction of granular-flow physics encountered in different regions of a Wurster bed. Our findings pave the way to using CFD-DEM to industrially-scaled Wurster-bed systems, which is currently unfeasible due to prohibitive computational costs.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Keyword
- Three-phase system
- CFD-DEM
- Liquid spray modelling
- Coarse-graining technique
- Granular flow regime characterisation
- Wurster fluidised-bed coater
Publication and Content Type
- art (subject category)
- ref (subject category)
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