Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

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Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

Razquin, Cristina (author): Universidad de Navarra,University of Navarra

Ruiz-Canela, Miguel (author): Universidad de Navarra,University of Navarra

Toledo, Estefania (author): Universidad de Navarra,University of Navarra

Clish, Clary B. (author): Broad Institute

Guasch-Ferré, Marta (author): Harvard School of Public Health, United States,Köpenhamns universitet,University of Copenhagen

García-Gavilán, Jesús F. (author)

Wittenbecher, Clemens, 1981 (author): Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology

Alonso-Gómez, Angel (author)

Fitó, Montse (author)

Liang, Liming (author): Harvard School of Public Health, United States

Corella, Dolores (author): Universitat de Valencia

Gómez-Gracia, Enrique (author): Universidad De Malaga,University of Malaga

Estruch, Ramon (author): Universitat de Barcelona,University of Barcelona

Fiol, Miquel (author)

Santos-Lozano, Jose M. (author)

Serra-Majem, Luis (author)

Ros, Emilio (author): Universitat de Barcelona,University of Barcelona

Aros, Fernando (author)

Salas-Salvadó, Jordi (author)

Hu, Frank B. (author): Harvard School of Public Health, United States

Martínez-González, Miguel A. (author): Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra

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(creator_code:org_t)

2022-12-23
2023
English.
In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 24:1

Related links:: https://research.cha... (primary) (free); show more...; https://doi.org/10.3...; https://research.cha...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61–0.99); 0.67 (0.51–0.86) and 0.75 (0.59–0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14–1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

amino acids
metabolomics
PREDIMED
case-cohort
peripheral artery disease

Publication and Content Type

art (subject category)
ref (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

Articles in the publication: International Jo ...

By the university: Chalmers University of Technology

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