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Imaging atheroscler...
Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
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- Skeoch, S. (author)
- Christie Hospital NHS Foundation Trust,University of Manchester
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- Hubbard Cristinacce, Penny L (author)
- University of Manchester
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- Williams, H. (author)
- Christie Hospital NHS Foundation Trust
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- Pemberton, P. (author)
- Christie Hospital NHS Foundation Trust
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- Xu, D. (author)
- University of Washington
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- Sun, J. (author)
- University of Washington
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- James, J. (author)
- Christie Hospital NHS Foundation Trust
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- Yuan, Chengyin (author)
- University of Washington
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- Hatsukami, T. (author)
- University of Washington
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- Hockings, Paul, 1956 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Alexander, M. Y. (author)
- Manchester Metropolitan University
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- Waterton, John C (author)
- University of Manchester
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- Bruce, I. N. (author)
- University of Manchester,Christie Hospital NHS Foundation Trust
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(creator_code:org_t)
- 2017-04-11
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 7:1
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Abstract
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- In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCEMRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). In this pilot study, RA patients and age/sex-matched controls were evaluated for cardiovascular risk factors and carotid plaque on ultrasound. Subjects with plaque >2 mm thick underwent DCE-MRI, and a subgroup of patients had FDG-PET. Comparison of MRI findings between groups and correlation between clinical, serological markers and imaging findings was undertaken. 130 patients and 62 controls were recruited. Plaque was more prevalent in the RA group (53.1% vs 37.0%, p = 0.038) and was independently associated with IL6 levels (HR[95% CI]: 2.03 [1.26, 3.26] per quartile). DCE-MRI data were available in 15 patients and 5 controls. Higher prevalence of plaque calcification was noted in RA, despite similar plaque size (73.3% vs 20%, p = 0.04). FDG-PET detected plaque inflammation in 12/13 patients scanned and degree of inflammation correlated with hs-CRP (r = 0.58, p = 0.04). This study confirms increased prevalence of atherosclerosis in RA and provides data to support the hypothesis that patients have a high-risk plaque phenotype.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Skeoch, S.
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Hubbard Cristina ...
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Williams, H.
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Pemberton, P.
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Xu, D.
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Sun, J.
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show more...
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James, J.
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Yuan, Chengyin
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Hatsukami, T.
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Hockings, Paul, ...
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Alexander, M. Y.
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Waterton, John C
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Bruce, I. N.
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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and Bioprocess Techn ...
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Scientific Repor ...
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Chalmers University of Technology