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Alginate and tunica...
Alginate and tunicate nanocellulose composite microbeads – Preparation, characterization and cell encapsulation
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- Kjesbu, Joachim S. (author)
- Norges teknisk-naturvitenskapelige universitet (NTNU),Norwegian University of Science and Technology (NTNU)
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- Zaytseva-Zotova, Daria (author)
- Norges teknisk-naturvitenskapelige universitet (NTNU),Norwegian University of Science and Technology (NTNU)
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- Sämfors, Sanna, 1987 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gatenholm, Paul, 1956 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Troedsson, Christofer (author)
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- Thompson, Eric M. (author)
- Universitetet i Bergen,University of Bergen
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- Strand, Berit Løkensgard (author)
- Norges teknisk-naturvitenskapelige universitet (NTNU),Norwegian University of Science and Technology (NTNU)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Carbohydrate Polymers. - : Elsevier BV. - 0144-8617. ; 286
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https://doi.org/10.1...
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Abstract
Subject headings
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- Alginate has been used for decades for cell encapsulation. Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production. We prepared microbeads of 400–600 μm of alginate and tunicate CNF. Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF. CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads. The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF. Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF. NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Annan teknik -- Livsmedelsteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies -- Food Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Keyword
- Microbeads
- Cellulose nanofibrils
- Tunicate
- Cell encapsulation
- Alginate
Publication and Content Type
- art (subject category)
- ref (subject category)
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