Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:research.chalmers.se:6665acd7-b156-4bf5-aede-fbc3fcf79e59" > Splenic Immune Resp...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Soni, Nikulkumar,1984Chalmers tekniska högskola,Chalmers University of Technology (author)

Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-01-10
MDPI AG,2017
electronicrdacarrier

Numbers

LIBRIS-ID:oai:research.chalmers.se:6665acd7-b156-4bf5-aede-fbc3fcf79e59
https://doi.org/10.3390/nu9010050DOI
https://research.chalmers.se/publication/246880URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

© 2017 by the authors; licensee MDPI, Basel, Switzerland. Dietary n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with reduction of inflammation, although the mechanisms are poorly understood, especially how the spleen, as a secondary lymphoid organ, is involved. To investigate the effects of EPA and DHA on spleen gene expression, male C57BL/6J mice were fed high fat diets (HFD) differing in fatty acid composition, either based on corn oil (HFD-CO), or CO enriched with 2 g/100 g EPA and DHA (HFD-ED), for eight weeks. Spleen tissue was analyzed using transcriptomics and for fatty acids profiling. Biological processes (BPs) related to the immune response, including T-cell receptor signaling pathway, T-cell differentiation and co-stimulation, myeloid dendritic cell differentiation, antigen presentation and processing, and the toll like receptor pathway were downregulated by HFD-ED compared with control and HFD-CO. These findings were supported by the down-regulation of NF-κB in HFD-ED compared with HFD-CO fed mice. Lower phospholipid arachidonic acid levels in HFD-ED compared with HFD-CO, and control mice suggest attenuation of pathways via prostaglandins and leukotrienes. The HFD-ED also upregulated BPs related to erythropoiesis and hematopoiesis compared with control and HFD-CO fed mice. Our findings suggest that EPA and DHA down-regulate the splenic immune response induced by HFD-CO, supporting earlier work that the spleen is a target organ for the anti-inflammatory effects of these n-3 fatty acids.

Subject headings and genre

NATURVETENSKAP Data- och informationsvetenskap hsv//swe
NATURAL SCIENCES Computer and Information Sciences hsv//eng
NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Ross, Alastair,1976Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)alastair (author)
Scheers, Nathalie,1974Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)kp01scna (author)
Savolainen, Otto,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sotto (author)
Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat (author)
Gabrielsson, Britt,1957Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)brittg (author)
Sandberg, Ann-Sofie,1951Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)annsandb (author)
Chalmers tekniska högskola (creator_code:org_t)

Related titles

In:Nutrients: MDPI AG9:1, s. 50-2072-66432072-6643

Internet link

Find in a library

Nutrients (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Soni, Nikulkumar ...; Ross, Alastair, ...; Scheers, Nathali ...; Savolainen, Otto ...; Nookaew, Intawat ...; Gabrielsson, Bri ...; show more...; Sandberg, Ann-So ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Computer and Inf ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences

Articles in the publication: Nutrients

By the university: Chalmers University of Technology

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se