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A Whole-Grain Diet ...
A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes
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- Malin, Steven K (author)
- University of Virginia,Cleveland Clinic Foundation
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- Kullman, Emily L (author)
- Cleveland State University,Cleveland Clinic Foundation
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- Scelsi, Amanda R (author)
- Cleveland Clinic Foundation
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- Godin, J. P. (author)
- Nestle S.A.
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- Ross, Alastair, 1976 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kirwan, J.P. (author)
- Cleveland Clinic Foundation
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(creator_code:org_t)
- 2019-03-20
- 2019
- English.
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In: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 63:7
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: The effect of whole-grain (WG) versus refined-grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function is unclear. Methods: In a double-blind crossover randomized controlled trial, 13 prediabetic adults (37.2 ± 1.8 y, BMI: 33.6 ± 1.4 kg m −2 , 2 h glucose: 146.9 ± 11.6 mg dL −1 ) are provided isocaloric-matched WG and RG diets for 8-weeks each, with an 8–10 week washout between diets. Glucose, insulin, and C-peptide are studied over 240 min following a 75 g OGTT. Incretins (GLP-1 and GIP), PYY, and total ghrelin are assessed at 0, 30, and 60 min. Mixed-meal diets for carbohydrate (54%), fat (28%), and protein (18%) contain either WG (50 g/1000 kcal) or equivalent RG. Results: Both diets induce fat loss (≈2 kg). While neither diet impacts early phase GSIS, the WG diet increases total GSIS (iAUC of C-peptide 0-240 /Glc 0-240 , p = 0.02) and β-cell function (disposition index; GSIS × insulin sensitivity, p = 0.02). GIP and PYY are unaltered by either diet, but GLP-1 is higher at 30 min following RG versus WG (p = 0.04). Ghrelin levels are higher at 60 min of the OGTT following both interventions (p = 0.01). Conclusion: A WG-rich diet increases β-cell function independent of gut hormones in adults with prediabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- alkylresorcinols
- low-glycemic diet
- insulin
- obesity
- glucose tolerance
Publication and Content Type
- art (subject category)
- ref (subject category)
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