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Serum metabolites a...
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Noerman, Stefania,1987Chalmers tekniska högskola,Chalmers University of Technology,Itä-Suomen Yliopisto,University of Eastern Finland
(författare)
Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2022-10-06
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Springer Science and Business Media LLC,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:6775cf08-9f92-4bbe-83d8-e60d474acb62
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https://research.chalmers.se/publication/532583URI
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https://doi.org/10.1007/s00394-022-03010-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Purpose: To identify fasting serum metabolites associated with WG intake in a free-living population adjusted for potential confounders. Methods: We selected fasting serum samples at baseline from a subset (n = 364) of the prospective population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) cohort. The samples were analyzed using nontargeted metabolomics with liquid chromatography coupled with mass spectrometry (LC–MS). Association with WG intake was investigated using both random forest followed by linear regression adjusted for age, BMI, smoking, physical activity, energy and alcohol consumption, and partial Spearman correlation adjusted for the same covariates. Features selected by any of these models were shortlisted for annotation. We then checked if we could replicate the findings in an independent subset from the same cohort (n = 200). Results: Direct associations were observed between WG intake and pipecolic acid betaine, tetradecanedioic acid, four glucuronidated alkylresorcinols (ARs), and an unknown metabolite both in discovery and replication cohorts. The associations remained significant (FDR<0.05) even after adjustment for the confounders in both cohorts. Sinapyl alcohol was positively correlated with WG intake in both cohorts after adjustment for the confounders but not in linear models in the replication cohort. Some microbial metabolites, such as indolepropionic acid, were positively correlated with WG intake in the discovery cohort, but the correlations were not replicated in the replication cohort. Conclusions: The identified associations between WG intake and the seven metabolites after adjusting for confounders in both discovery and replication cohorts suggest the potential of these metabolites as robust biomarkers of WG consumption.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Virtanen, Jyrki K.Itä-Suomen Yliopisto,University of Eastern Finland
(författare)
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Lehtonen, MarkoItä-Suomen Yliopisto,University of Eastern Finland
(författare)
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Brunius, Carl,1974Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)carlbru
(författare)
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Hanhineva, Kati,1972Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland(Swepub:cth)kati
(författare)
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Chalmers tekniska högskolaItä-Suomen Yliopisto
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Nutrition: Springer Science and Business Media LLC62:2, s. 713-7261436-62071436-6215
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