Enabling modular dosage form concepts for individualized multidrug therapy: Expanding the design window for poorly water-soluble drugs

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Govender, Rydvikha,1989Chalmers tekniska högskola,Chalmers University of Technology,AstraZeneca AB (author)

Enabling modular dosage form concepts for individualized multidrug therapy: Expanding the design window for poorly water-soluble drugs

Article/chapterEnglish2021

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Elsevier BV,2021
electronicrdacarrier

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LIBRIS-ID:oai:research.chalmers.se:76384845-91ae-439b-afb2-463fcc4f5bfb
https://doi.org/10.1016/j.ijpharm.2021.120625DOI
https://research.chalmers.se/publication/523791URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Multidrug dosage forms (aka combination dosage forms, polypills, etc.) create value for patients through reduced pill burdens and simplified administration to improve adherence to therapy. Enhanced flexibility of multidrug dosage forms would provide further opportunities to better match emerging needs for individualized therapy. Through modular dosage form concepts, one approach to satisfy these needs is to adapt multidrug dosage forms to a wider variety of drugs, each with a variety of doses and release profiles. This study investigates and technically explores design requirements for extending the capability of modular multidrug dosage form concepts towards individualization. This builds on our recent demonstration of independent tailoring of dose and drug release, which is here extended towards poorly water-soluble drugs. The challenging design requirement of carrying higher drug loads in smaller volumes to accommodate multiple drugs at their clinical dose is here met regarding dose and release performance. With a modular concept, we demonstrate high precision (<5% RSD) in dose and release performance of individual modules containing felodipine or naproxen in Kollidon VA64 at both a wide drug loading range (5% w/w and 50% w/w drug) and a small module size (3.6 mg). In a forward-looking design-based discussion, further requirements are addressed, emphasizing that reproducible individual module performance is predictive of dosage form performance, provided the modules are designed to act independently. Therefore, efforts to incorporate progressively higher drug loads within progressively smaller module volumes will be crucial to extend the design window further towards full flexibility of future dosage forms for individualized multidrug therapy.

Subject headings and genre

HUMANIORA Konst Design hsv//swe
HUMANITIES Arts Design hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
TEKNIK OCH TEKNOLOGIER Annan teknik Interaktionsteknik hsv//swe
ENGINEERING AND TECHNOLOGY Other Engineering and Technologies Interaction Technologies hsv//eng
Oral drug release
Amorphous solid dispersions
Melt extrusion
Flexible combinations
Polypharmacy
Mass customization

Added entries (persons, corporate bodies, meetings, titles ...)

Abrahmsén-Alami, SusannaAstraZeneca AB (author)
Folestad, StaffanAstraZeneca AB (author)
Olsson, Martina,1996Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)maolss (author)
Larsson, Anette,1966Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)anettel (author)
Chalmers tekniska högskolaAstraZeneca AB (creator_code:org_t)

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In:International Journal of Pharmaceutics: Elsevier BV6020378-51731873-3476

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