The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets

Viridén, Anna,1977Chalmers tekniska högskola,Chalmers University of Technology (author)

Polymer release from hydrophilic matrix tablets, composed of hydroxypropyl methylcellulose, was studied for seven different polymer batches. A time difference of more than 80h between fully dissolved tablets was noticed although the batches were of the same pharmaceutical substituent (USP 2208) and viscosity (100 cps) grade. To find the functionality related parameters for polymer release from hydrophilic matrix tablets the polymer samples were characterised according to size and chemical composition. The size of the polymers was characterised by size-exclusion chromatography with multi-angle light scattering and refractive index detection. The average amount of substituents was measured with nuclear magnetic resonance and the distribution of the substituents along the cellulose chain was determined with high-performance anion-exchange chromatography with pulsed amperometric detection after acid and enzymatic hydrolysis. The results indicated that other types of interactions apart from entanglements were present between the polymer chains, which seemed to affect the polymer release. Most importantly, this study has shown a correlation between the polymer release and the substituent pattern, where the samples with slow release also were more heterogeneously substituted along the polymer chain. From this we can conclude that polymer release is very sensitive to alterations in chemical composition.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
Magnetic Resonance Spectroscopy
Chromatography
*Polymers: CH
chemistry
chemistry
*Tablets
analogs & derivatives
Gel
Molecular Weight
*Methylcellulose: AA
Methylcellulose: CH
0 (Tablets)
0 (Polymers)

Wittgren, BengtAstraZeneca AB (author)
Andersson, ThomasAstraZeneca AB (author)
Larsson, Anette,1966Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)anettel (author)
Chalmers tekniska högskolaAstraZeneca AB (creator_code:org_t)

In:European journal of pharmaceutical sciences official journal of the European Federation for Pharmaceutical Sciences: Elsevier BV36:4-5, s. 392-4001879-0720
In:European Journal of Pharmaceutical Sciences: Elsevier BV36:4-5, s. 392-4000928-0987

By the author/editor: Viridén, Anna, 1 ...; Wittgren, Bengt; Andersson, Thoma ...; Larsson, Anette, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.