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  • Lappa, Dimitra,1988Chalmers tekniska högskola,Chalmers University of Technology (author)

Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-02
  • Public Library of Science (PLoS),2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:84bd2f61-33a5-40fe-904a-47ee8ea119cd
  • https://doi.org/10.1371/journal.pone.0279335DOI
  • https://research.chalmers.se/publication/534970URI
  • https://gup.ub.gu.se/publication/326146URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Weight loss through bariatric surgery is efficient for treatment or prevention of obesity related diseases such as type 2 diabetes and cardiovascular disease. Long term weight loss response does, however, vary among patients undergoing surgery. Thus, it is difficult to identify predictive markers while most obese individuals have one or more comorbidities. To overcome such challenges, an in-depth multiple omics analyses including fasting peripheral plasma metabolome, fecal metagenome as well as liver, jejunum, and adipose tissue transcriptome were performed for 106 individuals undergoing bariatric surgery. Machine leaning was applied to explore the metabolic differences in individuals and evaluate if metabolism-based patients' stratification is related to their weight loss responses to bariatric surgery. Using Self-Organizing Maps (SOMs) to analyze the plasma metabolome, we identified five distinct metabotypes, which were differentially enriched for KEGG pathways related to immune functions, fatty acid metabolism, protein-signaling, and obesity pathogenesis. The gut metagenome of the most heavily medicated metabotypes, treated simultaneously for multiple cardiometabolic comorbidities, was significantly enriched in Prevotella and Lactobacillus species. This unbiased stratification into SOM-defined metabotypes identified signatures for each metabolic phenotype and we found that the different metabotypes respond differently to bariatric surgery in terms of weight loss after 12 months. An integrative framework that utilizes SOMs and omics integration was developed for stratifying a heterogeneous bariatric surgery cohort. The multiple omics datasets described in this study reveal that the metabotypes are characterized by a concrete metabolic status and different responses in weight loss and adipose tissue reduction over time. Our study thus opens a path to enable patient stratification and hereby allow for improved clinical treatments.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Meijnikman, A. S.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Krautkramer, Kimberly A.Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xkraki (author)
  • Olsson, Lisa M.,1984Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xollit (author)
  • Aydin, O.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Van Rijswijk, Anne Sophie (author)
  • Acherman, Y. I.Z. (author)
  • de Brauw, Maurits (author)
  • Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtreva (author)
  • Olofsson, Louise,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xolofl (author)
  • Lundqvist, Annika,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xlannn (author)
  • Hjorth, S.Köpenhamns universitet,University of Copenhagen (author)
  • Ji, Boyang,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)boyang (author)
  • Gerdes, V. E.A.Universiteit Van Amsterdam,University of Amsterdam (author)
  • Groen, Albert K.Rijksuniversiteit Groningen,University of Groningen,Universiteit Van Amsterdam,University of Amsterdam (author)
  • Schwartz, Thue W.Köpenhamns universitet,University of Copenhagen (author)
  • Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xnieum (author)
  • Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbafre (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Chalmers tekniska högskolaUniversiteit Van Amsterdam (creator_code:org_t)

Related titles

  • In:PLoS ONE: Public Library of Science (PLoS)18:3, s. e0279335-1932-62031932-6203

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