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Control of mitochon...
Control of mitochondrial superoxide production includes programmed mtDNA deletion and restoration
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- Stenberg, Simon (author)
- Göteborgs universitet,University of Gothenburg,Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU)
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- Li, Jing (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Gjuvsland, Arne B (author)
- Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU)
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- Persson, Karl, 1988 (author)
- Göteborgs universitet,University of Gothenburg
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- Demitz-Helin, Erik (author)
- Göteborgs universitet,University of Gothenburg
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- Yue, Jia Xing (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Gilchrist, Ciaran (author)
- Göteborgs universitet,University of Gothenburg
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- Ärengård, Timmy (author)
- Göteborgs universitet,University of Gothenburg
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- Ghiaci, Payam (author)
- Göteborgs universitet,University of Gothenburg
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- Larsson-Berglund, Lisa (author)
- Göteborgs universitet,University of Gothenburg
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- Zackrisson, Martin (author)
- Göteborgs universitet,University of Gothenburg
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- Höög, Johanna, 1979 (author)
- Göteborgs universitet,University of Gothenburg
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- Molin, Mikael, 1973 (author)
- Göteborgs universitet,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Liti, Gianni (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Omholt, Stig (author)
- Norges teknisk-naturvitenskapelige universitet (NTNU),Norwegian University of Science and Technology (NTNU)
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- Warringer, Jonas, 1973 (author)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2020
- 2020
- English.
- Related links:
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https://www.biorxiv....
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Subject headings
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- Deletion of mitochondrial DNA in eukaryotes is mainly attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that the regulatory circuitry underlying this editing critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. Our results may therefore be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.One-Sentence SummaryGenetically controlled editing of mitochondrial DNA is an integral part of the yeast’s defenses against oxidative damage.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- vet (subject category)
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- By the author/editor
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Stenberg, Simon
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Li, Jing
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Gjuvsland, Arne ...
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Persson, Karl, 1 ...
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Demitz-Helin, Er ...
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Yue, Jia Xing
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Gilchrist, Ciara ...
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Ärengård, Timmy
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Ghiaci, Payam
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Larsson-Berglund ...
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Zackrisson, Mart ...
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Höög, Johanna, 1 ...
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Molin, Mikael, 1 ...
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Liti, Gianni
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Omholt, Stig
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Warringer, Jonas ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- By the university
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Chalmers University of Technology