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The molecular basis...
The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
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- Frandsen, K. E. H. (author)
- Köpenhamns universitet,University of Copenhagen
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- Simmons, T. J. (author)
- University Of Cambridge
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- Dupree, P. (author)
- University Of Cambridge
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- Poulsen, J. C. N. (author)
- Köpenhamns universitet,University of Copenhagen
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- Hemsworth, G. R. (author)
- University of York
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- Ciano, L. (author)
- University of York
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- Johnston, E. M. (author)
- University of York
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- Tovborg, M. (author)
- Novozymes A/S
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- Salomon Johansen, Katja, 1969 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- von Freiesleben, P. (author)
- Novozymes A/S
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- Marmuse, L. (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Fort, S. (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Cottaz, S. (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Driguez, H. (author)
- Université Grenoble Alpes,Grenoble Alpes University
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- Henrissat, B. (author)
- King Abdulaziz University,Aix-Marseille Université,Aix Marseille University
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- Lenfant, N. (author)
- Aix-Marseille Université,Aix Marseille University
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- Tuna, F. (author)
- University of Manchester
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- Baldansuren, A. (author)
- University of Manchester
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- Davies, G. J. (author)
- University of York
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- Lo Leggio, L. (author)
- Köpenhamns universitet,University of Copenhagen
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- Walton, P. H. (author)
- University of York
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(creator_code:org_t)
- 2016-02-29
- 2016
- English.
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In: Nature Chemical Biology. - : Springer Science and Business Media LLC. - 1552-4450 .- 1552-4469. ; 12:4, s. 298-
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http://dx.doi.org/10...
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Abstract
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- Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that oxidatively break down recalcitrant polysaccharides such as cellulose and chitin. Since their discovery, LPMOs have become integral factors in the industrial utilization of biomass, especially in the sustainable generation of cellulosic bioethanol. We report here a structural determination of an LPMO-oligosaccharide complex, yielding detailed insights into the mechanism of action of these enzymes. Using a combination of structure and electron paramagnetic resonance spectroscopy, we reveal the means by which LPMOs interact with saccharide substrates. We further uncover electronic and structural features of the enzyme active site, showing how LPMOs orchestrate the reaction of oxygen with polysaccharide chains.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Frandsen, K. E. ...
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Simmons, T. J.
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Dupree, P.
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Poulsen, J. C. N ...
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Hemsworth, G. R.
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Ciano, L.
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show more...
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Johnston, E. M.
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Tovborg, M.
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Salomon Johansen ...
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von Freiesleben, ...
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Marmuse, L.
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Fort, S.
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Cottaz, S.
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Driguez, H.
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Henrissat, B.
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Lenfant, N.
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Tuna, F.
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Baldansuren, A.
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Davies, G. J.
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Lo Leggio, L.
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Walton, P. H.
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
- Articles in the publication
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Nature Chemical ...
- By the university
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Chalmers University of Technology