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Metagenomic analysi...
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Das, Promi,1990Chalmers tekniska högskola,Chalmers University of Technology
(author)
Metagenomic analysis of bile salt biotransformation in the human gut microbiome
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-06-25
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Springer Science and Business Media LLC,2019
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:research.chalmers.se:8c9d1a9c-97fd-424d-b763-bc633b60efdd
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https://research.chalmers.se/publication/511693URI
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https://doi.org/10.1186/s12864-019-5899-3DOI
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https://research.chalmers.se/publication/511360URI
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https://research.chalmers.se/publication/511228URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human physiology. Several 16S amplicon-based studies with inflammatory bowel disease (IBD) subjects were found to have an association with the level of fecal bile acids. However, a detailed investigation of all the bile salt biotransformation genes in the gut microbiome of healthy and IBD subjects has not been performed. Results: Here, we report a comprehensive analysis of the bile salt biotransformation genes and their distribution at the phyla level. Based on the analysis of shotgun metagenomes, we found that the IBD subjects harbored a significantly lower abundance of these genes compared to the healthy controls. Majority of these genes originated from Firmicutes in comparison to other phyla. From metabolomics data, we found that the IBD subjects were measured with a significantly low level of secondary bile acids and high levels of primary bile acids compared to that of the healthy controls. Conclusions: Our bioinformatics-driven approach of identifying bile salt biotransformation genes predicts the bile salt biotransformation potential in the gut microbiota of IBD subjects. The functional level of dysbiosis likely contributes to the variation in the bile acid pool. This study sets the stage to envisage potential solutions to modulate the gut microbiome with the objective to restore the bile acid pool in the gut.
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Marcisauskas, Simonas,1988Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)simmarc
(author)
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Ji, Boyang,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)bojand
(author)
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Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology,Danmarks Tekniske Universitet,Technical University of Denmark(Swepub:cth)nielsenj
(author)
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Chalmers tekniska högskolaDanmarks Tekniske Universitet
(creator_code:org_t)
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In:BMC Genomics: Springer Science and Business Media LLC20:11471-2164
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