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The Antennapedia pe...
The Antennapedia peptide penetratin translocates across lipid bilayers - the first direct observation
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- Thoren, Per, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Persson, Daniel, 1972 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Karlsson, M. (author)
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- Nordén, Bengt, 1945 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: FEBS Letters. - 1873-3468 .- 0014-5793. ; 482:3, s. 265-268
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The potential use of polypeptides and oligonucleotides for therapeutical purposes has been questioned because of their inherently poor cellular uptake. However, the 16-mer oligopeptide penetratin, derived from the homeodomain of Antennapedia, has been reported to enter cells readily via a non-endocytotic and receptor- and transporter-independent pathway, even when conjugated to large hydrophilic molecules. We here present the first study where penetratin is shown to traverse a pure lipid bilayer. The results support the idea that the uptake mechanism involves only the interaction of the peptide with the membrane lipids. Furthermore, we conclude that the translocation does not involve pore formation.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- antennapedia homeodomain
- uptake
- penetratin
- membrane translocation
- delivery vector
Publication and Content Type
- art (subject category)
- ref (subject category)
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