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Plasma metabolite b...
Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk
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- Shi, Lin, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Shaanxi Normal University
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- Brunius, Carl, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi,Näringsforskning
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- Bergdahl, Ingvar (author)
- Umeå universitet,Enheten för biobanksforskning,Avdelningen för medicin,Arcum
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Winkvist, Anna, 1962 (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Avdelningen för hållbar hälsa,University of Gothenburg, Gothenburg
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- Hanhineva, K. (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Landberg, Rikard, 1981 (author)
- Umeå universitet,Kardiologi,Department of Biology andBiological Engineering, Chalmers University of Technology, Gothenburg
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(creator_code:org_t)
- Wiley, 2020
- 2020
- English.
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In: Journal of Internal Medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 287:4, s. 405-421
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Abstract
Subject headings
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- Habitual coffee intake has been associated with a lower risk of developing type 2 diabetes (T2D), but few studies used biomarkers to reflect intake and investigated different coffee brews, that is boiled and filtered, separately. Objectives: To identify plasma metabolites associated with boiled or filtered coffee intake and to examine their association with T2D risk in Swedish adults. Methods: In a case–control study nested within the Västerbotten Intervention Programme, baseline plasma samples from 421 case–control pairs and samples from a subset of 149 pairs at a 10-year follow-up were analysed using untargeted LC-MS metabolomics. We identified metabolites associated with food frequency questionnaires (FFQ)-estimated coffee intake and assessed odds ratios of T2D. Results: In total, 24 and 32 metabolites were associated with boiled or filtered coffee intake. We determined robust metabolite panels for highly specific prediction of boiled or filtered coffee. We observed an inverse association between the metabolite panel of filtered coffee and T2D risk. No association with T2D was observed for the panel of boiled coffee intake. Similar results were observed for FFQ-estimated coffee intake. Conclusions: We identified plasma metabolites specifically associated with boiled or filtered coffee intake, which might be used as selective biomarkers. Our study supports a protective role of habitual intake of filtered coffee on T2D development. The lack of association for boiled coffee intake might be due to the lack of a protective effect of boiled coffee or due to the limited number of boiled coffee consumers in this population, but it warrants further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- epidemiology
- coffee intake
- dietary biomarker
- type 2 diabetes
- metabolomics
- coffee intake
- dietary biomarker
- epidemiology
- metabolomics
- type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Shi, Lin, 1988
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Brunius, Carl, 1 ...
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Johansson, Ingeg ...
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Bergdahl, Ingvar
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Rolandsson, Olov
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van Guelpen, Bet ...
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show more...
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Winkvist, Anna, ...
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Hanhineva, K.
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Landberg, Rikard ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Journal of Inter ...
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Chalmers University of Technology
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University of Gothenburg
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Umeå University