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The Influence of Mi...
The Influence of Microgravity on Invasive Growth in Saccharomyces cerevisiae
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- Van Mulders, S. E. (author)
- Katholieke Universiteit Leuven
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- Stassen, C. (author)
- Universiteit Gent,Ghent university
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- Daenen, L. (author)
- Katholieke Universiteit Leuven
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- Devreese, B. (author)
- Universiteit Gent,Ghent university
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- Siewers, Verena, 1976 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- van Eijsden, R. G. E. (author)
- Flanders Interuniversity Institute for Biotechnology
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Delvaux, F. R. (author)
- Katholieke Universiteit Leuven
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- Willaert, R. G. (author)
- Vrije Universiteit Brüssel (VUB),Vrije Universiteit Brussel (VUB)
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2011
- 2011
- English.
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In: Astrobiology. - : Mary Ann Liebert Inc. - 1531-1074 .- 1557-8070. ; 11:1, s. 45-55
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http://dx.doi.org/10...
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Abstract
Subject headings
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- This study investigates the effects of microgravity on colony growth and the morphological transition from single cells to short invasive filaments in the model eukaryotic organism Saccharomyces cerevisiae. Two-dimensional spreading of the yeast colonies grown on semi-solid agar medium was reduced under microgravity in the Sigma 1278b laboratory strain but not in the CMBSESA1 industrial strain. This was supported by the Sigma 1278b proteome map under microgravity conditions, which revealed upregulation of proteins linked to anaerobic conditions. The Sigma 1278b strain showed a reduced invasive growth in the center of the yeast colony. Bud scar distribution was slightly affected, with a switch toward more random budding. Together, microgravity conditions disturb spatially programmed budding patterns and generate strain-dependent growth differences in yeast colonies on semi-solid medium.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- yeast
- Adhesion
- shear modeled microgravity
- escherichia-coli
- international-space-station
- candida-albicans
- Budding
- Microgravity
- Invasive growth
- cell-cell
- immune-system
- biofilm formation
- Saccharomyces cerevisiae
- stress-response
- Proteomics
- gene-expression
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Van Mulders, S. ...
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Stassen, C.
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Daenen, L.
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Devreese, B.
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Siewers, Verena, ...
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van Eijsden, R. ...
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show more...
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Nielsen, Jens B, ...
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Delvaux, F. R.
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Willaert, R. G.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Astrobiology
- By the university
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Chalmers University of Technology