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Biomarkers of seafo...
Biomarkers of seafood intake during pregnancy – Pollutants versus fatty acids and micronutrients
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- Stråvik, Mia, 1994 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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- Gustin, Klara (author)
- Karolinska Institutet
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- Barman, Malin, 1983 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Karolinska Institutet,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden; Institute of Environmental Medicine, Unit of Metals and Health, Karolinska Institutet, Stockholm, Sweden
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- Levi, Michael (author)
- Karolinska Institutet
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- Sandin, Anna (author)
- Umeå universitet,Pediatrik
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- Wold, Agnes E, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Sandberg, Ann-Sofie, 1951 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Life Sciences, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
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- Kippler, Maria (author)
- Karolinska Institutet
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- Vahter, Marie (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 225
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Abstract
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- Intake of fish and seafood during pregnancy may have certain beneficial effects on fetal development, but measurement of intake using questionnaires is unreliable. Here, we assessed several candidate biomarkers of seafood intake, including long-chain omega 3 fatty acids (n-3 LCPUFA), selenium, iodine, methylmercury, and different arsenic compounds, in 549 pregnant women (gestational week 29) in the prospective birth cohort NICE (Nutritional impact on Immunological maturation during Childhood in relation to the Environment). Proportions of the fatty acids eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) in erythrocytes were measured using gas chromatography with flame ionization detector. Selenium was measured in blood plasma and erythrocytes, mercury and arsenic in erythrocytes, and iodine and several arsenic compounds in urine, using inductively coupled plasma mass spectrometry, arsenic compounds after first being separated by ion exchange high-performance liquid chromatography (HPLC). Each biomarker was related to intake of total seafood and to intake of fatty and lean fish, and shellfish in third trimester, estimated from a semi-quantitative food frequency questionnaire filled out in gestational week 34. The pregnant women reported a median total seafood intake of 184 g/week (5th-95th percentiles: 34–465 g/week). This intake correlated most strongly with erythrocyte mercury concentrations (rho = 0.49, p < 0.001), consisting essentially of methylmercury, followed by total arsenic in erythrocytes (rho = 0.34, p < 0.001), and arsenobetaine in urine (rho = 0.33, p < 0.001), the main form of urinary arsenic. These biomarkers correlated well with intake of both fatty fish, lean fish, and shellfish. Erythrocyte DHA and plasma selenium correlated, although weakly, mainly with fatty fish (rho = 0.25 and 0.22, respectively, both p < 0.001). In conclusion, elevated concentrations of erythrocyte mercury and urinary arsenobetaine can be useful indicators of seafood intake, more so than the n-3 LCPUFAs. However, the relative importance of the biomarkers may differ depending on the type and amount of seafood consumed.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Mercury
- Seafood biomarkers
- Fish
- Arsenic
- Fatty acids
- Pregnancy
- Seafood biomarkers
- Fish
- Pregnancy
- Mercury
- Arsenic
- Fatty acids
Publication and Content Type
- art (subject category)
- ref (subject category)
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Stråvik, Mia, 19 ...
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Gustin, Klara
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Barman, Malin, 1 ...
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Levi, Michael
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Sandin, Anna
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Wold, Agnes E, 1 ...
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Sandberg, Ann-So ...
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Kippler, Maria
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Vahter, Marie
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environmental Re ...
- By the university
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Chalmers University of Technology
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University of Gothenburg
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Umeå University
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Karolinska Institutet