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The Silicon Trypano...
The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology
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- Achcar, F. (author)
- University of Glasgow
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- Fadda, A. (author)
- Ruprecht-Karls-Universität Heidelberg,Heidelberg University
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- Haanstra, J. R. (author)
- Rijksuniversiteit Groningen,University of Groningen,Vrije Universiteit Amsterdam (VU)
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- Kerkhoven, Eduard, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kim, D. H. (author)
- Wellcome Trust Centre for Molecular Parasitology
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- Leroux, A. E. (author)
- Ruprecht-Karls-Universität Heidelberg,Heidelberg University
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- Papamarkou, T. (author)
- University College London (UCL)
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- Rojas, F. (author)
- University of Edinburgh
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- Bakker, B.M. (author)
- Rijksuniversiteit Groningen,University of Groningen
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- Barrett, M. P. (author)
- Wellcome Trust Centre for Molecular Parasitology
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- Clayton, C. (author)
- Ruprecht-Karls-Universität Heidelberg,Heidelberg University
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- Girolami, M. (author)
- University College London (UCL)
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- Krauth-Siegel, R. L. (author)
- Ruprecht-Karls-Universität Heidelberg,Heidelberg University
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- Matthews, K. R. (author)
- University of Edinburgh
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- Breitling, R. (author)
- University of Manchester
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(creator_code:org_t)
- ISBN 9780128001431
- Elsevier, 2014
- 2014
- English.
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In: Advances in Microbial Physiology. - : Elsevier. - 0065-2911. - 9780128001431 ; 64, s. 115-143
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Abstract
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- The African trypanosome, Ttypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.
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Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publication and Content Type
- kap (subject category)
- vet (subject category)
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- By the author/editor
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Achcar, F.
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Fadda, A.
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Haanstra, J. R.
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Kerkhoven, Eduar ...
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Kim, D. H.
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Leroux, A. E.
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show more...
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Papamarkou, T.
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Rojas, F.
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Bakker, B.M.
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Barrett, M. P.
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Clayton, C.
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Girolami, M.
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Krauth-Siegel, R ...
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Matthews, K. R.
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Breitling, R.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Advances in Micr ...
- By the university
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Chalmers University of Technology