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A compartmental CFD...
A compartmental CFD-PBM model of high shear wet granulation
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- Yu, X. (author)
- Aston University,University of Sheffield
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- Hounslow, M.J. (author)
- University of Sheffield
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- Reynolds, G.K. (author)
- AstraZeneca AB
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- Rasmuson, Anders, 1951 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Niklasson Björn, I. (author)
- AstraZeneca AB
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- Abrahamsson, Per, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2016-07-15
- 2017
- English.
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In: AICHE Journal. - : Wiley. - 1547-5905 .- 0001-1541. ; 63:2, s. 438-458
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Abstract
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- © 2016 American Institute of Chemical EngineersThe conventional, geometrically lumped description of the physical processes inside a high shear granulator is not reliable for process design and scale-up. In this study, a compartmental Population Balance Model (PBM) with spatial dependence is developed and validated in two lab-scale high shear granulation processes using a 1.9L MiPro granulator and 4L DIOSNA granulator. The compartmental structure is built using a heuristic approach based on computational fluid dynamics (CFD) analysis, which includes the overall flow pattern, velocity and solids concentration. The constant volume Monte Carlo approach is implemented to solve the multi-compartment population balance equations. Different spatial dependent mechanisms are included in the compartmental PBM to describe granule growth. It is concluded that for both cases (low and high liquid content), the adjustment of parameters (e.g. layering, coalescence and breakage rate) can provide a quantitative prediction of the granulation process. © 2016 American Institute of Chemical Engineers AIChE J, 63: 438–458, 2017.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Strömningsmekanik och akustik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Fluid Mechanics and Acoustics (hsv//eng)
Keyword
- CFD
- high shear wet granulation
- Monte Carlo
- population balance model
- multiple compartments
Publication and Content Type
- art (subject category)
- ref (subject category)
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