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Calculation of Ener...
Calculation of Energy-Deposition Distributions and Microdosimetric Estimation of the Biological Effect of a 9C Beam
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- Mancusi, Davide, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sihver, Lembit, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Niita, K. (author)
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Li, Q (author)
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Sato, T. (author)
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Iwase, H. (author)
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Iwamoto, Y. (author)
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Matsuda, N. (author)
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Sakamoto, Y. (author)
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Nakashima, H. (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Radiation and Environmental Biophysics. - 1432-2099 .- 0301-634X. ; 48:2, s. 135-143
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Abstract
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- Among the alternative beams being recently considered for external cancer radiotherapy, C-9 has received some attention because it is expected that its biological effectiveness could be boosted by the beta-delayed emission of two alpha particles and a proton that takes place at the ion-stopping site. Experiments have been performed to characterise this exotic beam physically and models have been developed to estimate quantitatively its biological effect. Here, the particle and heavy-ion transport code system (PHITS ) is used to calculate energy-deposition and linear energy transfer distributions for a C-9 beam in water and the results are compared with published data. Although PHITS fails to reproduce some of the features of the distributions, it suggests that the decay of C-9 contributes negligibly to the energy-deposition distributions, thus contradicting the previous interpretation of the measured data. We have also performed a microdosimetric calculation to estimate the biological effect of the decay, which was found to be negligible; previous microdosimetric Monte-Carlo calculations were found to be incorrect. An analytical argument, of geometrical nature, confirms this conclusion and gives a theoretical upper bound on the additional biological effectiveness of the decay. However, no explanation can be offered at present for the observed difference in the biological effectiveness between C-9 and C-12; the reproducibility of this surprising result will be verified in coming experiments.
Subject headings
- NATURVETENSKAP -- Fysik -- Subatomär fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Subatomic Physics (hsv//eng)
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- art (subject category)
- ref (subject category)
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Mancusi, Davide, ...
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Sihver, Lembit, ...
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Niita, K.
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Li, Q
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Sato, T.
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Iwase, H.
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show more...
-
Iwamoto, Y.
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Matsuda, N.
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Sakamoto, Y.
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Nakashima, H.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Subatomic Physic ...
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Radiation and En ...
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Chalmers University of Technology