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Gut microbiota medi...
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
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- Liu, Zhigang (author)
- Northwest A&F university
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- Dai, Xiaoshuang (author)
- BGI Institute of Applied Agriculture
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- Zhang, Hongbo (author)
- Northwest A&F university
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- Shi, Renjie (author)
- Northwest A&F university
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- Hui, Yan (author)
- BGI Institute of Applied Agriculture,Köpenhamns universitet,University of Copenhagen
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- Jin, Xin (author)
- BGI Institute of Applied Agriculture
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- Zhang, Wentong (author)
- Northwest A&F university
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- Wang, Luanfeng (author)
- Northwest A&F university
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- Wang, Qianxu (author)
- Northwest A&F university
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- Wang, Danna (author)
- Northwest A&F university
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- Wang, Jia (author)
- Northwest A&F university
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- Tan, Xintong (author)
- Northwest A&F university
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- Ren, Bo (author)
- Northwest A&F university
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- Liu, Xiaoning (author)
- Northwest A&F university
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- Zhao, Tong (author)
- Northwest A&F university
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- Wang, Jiamin (author)
- Northwest A&F university
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- Pan, Junru (author)
- Northwest A&F university
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- Yuan, Tian (author)
- Northwest A&F university
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- Chu, Chuanqi (author)
- Northwest A&F university
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- Lan, Lei (author)
- BGI Institute of Applied Agriculture
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- Yin, Fei (author)
- University of Arizona
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- Cadenas, Enrique (author)
- University of Southern California
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- Shi, Lin, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Zhao, Shancen (author)
- BGI Institute of Applied Agriculture
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- Liu, Xuebo (author)
- Northwest A&F university
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(creator_code:org_t)
- 2020-02-18
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1, s. 855-
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Abstract
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- Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Liu, Zhigang
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Dai, Xiaoshuang
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Zhang, Hongbo
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Shi, Renjie
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Hui, Yan
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Jin, Xin
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show more...
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Zhang, Wentong
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Wang, Luanfeng
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Wang, Qianxu
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Wang, Danna
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Wang, Jia
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Tan, Xintong
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Ren, Bo
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Liu, Xiaoning
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Zhao, Tong
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Wang, Jiamin
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Pan, Junru
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Yuan, Tian
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Chu, Chuanqi
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Lan, Lei
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Yin, Fei
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Cadenas, Enrique
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Shi, Lin, 1988
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Zhao, Shancen
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Liu, Xuebo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Nature Communica ...
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Chalmers University of Technology