Search: onr:"swepub:oai:research.chalmers.se:a4eb037a-4f83-49cf-b954-a12d21083f72" >
Gut microbiota medi...
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Liu, ZhigangNorthwest A&F university
(author)
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-02-18
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Springer Science and Business Media LLC,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:research.chalmers.se:a4eb037a-4f83-49cf-b954-a12d21083f72
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https://doi.org/10.1038/s41467-020-14676-4DOI
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https://research.chalmers.se/publication/515689URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
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Dai, XiaoshuangBGI Institute of Applied Agriculture
(author)
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Zhang, HongboNorthwest A&F university
(author)
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Shi, RenjieNorthwest A&F university
(author)
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Hui, YanBGI Institute of Applied Agriculture,Köpenhamns universitet,University of Copenhagen
(author)
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Jin, XinBGI Institute of Applied Agriculture
(author)
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Zhang, WentongNorthwest A&F university
(author)
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Wang, LuanfengNorthwest A&F university
(author)
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Wang, QianxuNorthwest A&F university
(author)
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Wang, DannaNorthwest A&F university
(author)
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Wang, JiaNorthwest A&F university
(author)
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Tan, XintongNorthwest A&F university
(author)
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Ren, BoNorthwest A&F university
(author)
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Liu, XiaoningNorthwest A&F university
(author)
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Zhao, TongNorthwest A&F university
(author)
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Wang, JiaminNorthwest A&F university
(author)
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Pan, JunruNorthwest A&F university
(author)
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Yuan, TianNorthwest A&F university
(author)
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Chu, ChuanqiNorthwest A&F university
(author)
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Lan, LeiBGI Institute of Applied Agriculture
(author)
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Yin, FeiUniversity of Arizona
(author)
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Cadenas, EnriqueUniversity of Southern California
(author)
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Shi, Lin,1988Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)shlin
(author)
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Zhao, ShancenBGI Institute of Applied Agriculture
(author)
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Liu, XueboNorthwest A&F university
(author)
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Northwest A&F universityBGI Institute of Applied Agriculture
(creator_code:org_t)
Related titles
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In:Nature Communications: Springer Science and Business Media LLC11:1, s. 855-2041-17232041-1723
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- By the author/editor
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Liu, Zhigang
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Dai, Xiaoshuang
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Zhang, Hongbo
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Shi, Renjie
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Hui, Yan
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Jin, Xin
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show more...
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Zhang, Wentong
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Wang, Luanfeng
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Wang, Qianxu
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Wang, Danna
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Wang, Jia
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Tan, Xintong
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Ren, Bo
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Liu, Xiaoning
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Zhao, Tong
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Wang, Jiamin
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Pan, Junru
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Yuan, Tian
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Chu, Chuanqi
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Lan, Lei
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Yin, Fei
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Cadenas, Enrique
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Shi, Lin, 1988
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Zhao, Shancen
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Liu, Xuebo
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Chalmers University of Technology