Search: onr:"swepub:oai:research.chalmers.se:a822a918-6f9e-489c-afad-0963d038e057" >
Pyrene Functionaliz...
Pyrene Functionalized Norbornadiene-Quadricyclane Fluorescent Photoswitches: Characterization of their Spectral Properties and Application in Imaging of Amyloid Beta Plaques
-
- Ghasemi, Shima, 1993 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Shamsabadi, Monika, 1997 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Olesund, Axel, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
show more...
-
- Najera, Francisco (author)
- Universidad De Malaga,University of Malaga
-
- Erbs Hillers-Bendtsen, Andreas (author)
- Köpenhamns universitet,University of Copenhagen
-
- Edhborg, Fredrik, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Adil Salman Aslam, Muhammad, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Larsson, Wera, 1992 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Wang, Zhihang, 1989 (author)
- University Of Cambridge
-
- Amombo Noa, Francoise Mystere, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Salthouse, Rebecca J. (author)
- Universitat Politecnica de Catalunya,Polytechnic University of Catalonia
-
- Öhrström, Lars, 1963 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Hölzel, Helen (author)
- Universitat Politecnica de Catalunya,Polytechnic University of Catalonia
-
- Perez-Inestrosa, E. (author)
- Universidad De Malaga,University of Malaga
-
- Mikkelsen, Kurt V. (author)
- Köpenhamns universitet,University of Copenhagen
-
- Hanrieder, Jörg, 1980 (author)
- University College London (UCL),Göteborgs universitet,University of Gothenburg
-
- Albinsson, Bo, 1963 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Dreos, Ambra, 1987 (author)
- Göteborgs universitet,University of Gothenburg
-
- Moth-Poulsen, Kasper, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Universitat Politecnica de Catalunya,Polytechnic University of Catalonia,Institut de Ciència de Materials de Barcelona (ICMAB-CSIC),Institute of Material Science of Barcelona (ICMAB),Institucio Catalana de Recerca i Estudis Avancats (ICREA),Catalan Institution for Research and Advanced Studies (ICREA)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Chemistry - A European Journal. - 1521-3765 .- 0947-6539. ; 30:34
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://research.cha...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- This study presents the synthesis and characterization of two fluorescent norbornadiene (NBD) photoswitches, each incorporating two conjugated pyrene units. Expanding on the limited repertoire of reported photoswitchable fluorescent NBDs, we explore their properties with a focus on applications in bioimaging of amyloid beta (Aβ) plaques. While the fluorescence emission of the NBD decreases upon photoisomerization, aligning with what has been previously reported, for the first time we observed luminescence after irradiation of the quadricyclane (QC) isomer. We deduce how the observed emission is induced by photoisomerization to the excited state of the parent isomer (NBD) which is then the emitting species. Thorough characterizations including NMR, UV-Vis, fluorescence, X-ray structural analysis and density functional theory (DFT) calculations provide a comprehensive understanding of these systems. Notably, one NBD-QC system exhibits exceptional durability. Additionally, these molecules serve as effective fluorescent stains targeting Aβ plaques in situ, with observed NBD/QC switching within the plaques. Molecular docking simulations explore NBD interactions with amyloid, unveiling novel binding modes. These insights mark a crucial advancement in the comprehension and design of future photochromic NBDs for bioimaging applications and beyond, emphasizing their potential in studying and addressing protein aggregates.
Subject headings
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- photoswitches
- Norbornadienes
- Alzheimer
- photochromism
- imaging
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ghasemi, Shima, ...
-
Shamsabadi, Moni ...
-
Olesund, Axel, 1 ...
-
Najera, Francisc ...
-
Erbs Hillers-Ben ...
-
Edhborg, Fredrik ...
-
show more...
-
Adil Salman Asla ...
-
Larsson, Wera, 1 ...
-
Wang, Zhihang, 1 ...
-
Amombo Noa, Fran ...
-
Salthouse, Rebec ...
-
Öhrström, Lars, ...
-
Hölzel, Helen
-
Perez-Inestrosa, ...
-
Mikkelsen, Kurt ...
-
Hanrieder, Jörg, ...
-
Albinsson, Bo, 1 ...
-
Dreos, Ambra, 19 ...
-
Moth-Poulsen, Ka ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Physical Science ...
-
and Atom and Molecul ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Materials Chemis ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Organic Chemistr ...
- Articles in the publication
-
Chemistry - A Eu ...
- By the university
-
Chalmers University of Technology